鉴定一种具有极长富含半胱氨酸区域的PC6同工型，PC6是一种类似Kex2的加工内切蛋白酶。
Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease.
作者信息
Nakagawa T, Murakami K, Nakayama K
机构信息
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
出版信息
FEBS Lett. 1993 Jul 26;327(2):165-71. doi: 10.1016/0014-5793(93)80163-o.
In the previous study [1993, J. Biochem. (Tokyo) 113, 132-135] we identified PC6, a member of the Kex2 family of processing endoproteases. In this study, we identified another cDNA encoding an isoform of PC6, and designated it as PC6B and redesignated the originally identified PC6 as PC6A. PC6B had a very large Cys-rich region consisting of 22-times repeats of a Cys-rich motif, and a putative transmembrane domain which is not present in PC6A. A PC6B transcript was found mainly in the intestine, while PC6A transcripts were in various tissues. These results suggest distinct roles of PC6A and PC6B in endoproteolytic processing of precursor proteins.
在之前的研究中[1993年，《生物化学杂志》（东京）113卷，第132 - 135页]，我们鉴定出PC6，它是加工性内切蛋白酶Kex2家族的一员。在本研究中，我们鉴定出另一个编码PC6异构体的cDNA，并将其命名为PC6B，同时将最初鉴定的PC6重新命名为PC6A。PC6B有一个非常大的富含半胱氨酸的区域，由富含半胱氨酸基序的22次重复组成，还有一个PC6A中不存在的推定跨膜结构域。PC6B转录本主要在肠道中发现，而PC6A转录本存在于各种组织中。这些结果表明PC6A和PC6B在前体蛋白的内切蛋白水解加工中具有不同的作用。
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