Roulet Perez E, Davidoff V, Despland P A, Deonna T
Service de Pédiatrie, CHUV, Lausanne, Switzerland.
Dev Med Child Neurol. 1993 Aug;35(8):661-74. doi: 10.1111/j.1469-8749.1993.tb11711.x.
Four children with 'epilepsy and continuous spike-wave sleep' syndrome and mental and behavioural regression were followed prospectively with neuropsychological tests, behavioural questionnaires and sleep EEG performed at regular intervals between 1 1/2 and four years of age. The children showed a pattern of behavioural and cognitive disturbances similar to that found in some developmental autistic-like disorders, but also in adult frontal syndrome. Deterioration was probably due to an unusual long-standing epileptic dysfunction involving the frontal lobes. The process is potentially reversible and seems to be the same as postulated for acquired epileptic aphasia, but in a different localization.
对4名患有“癫痫伴睡眠期持续棘慢波”综合征且有精神和行为倒退的儿童进行了前瞻性研究，在1.5至4岁期间定期进行神经心理测试、行为问卷和睡眠脑电图检查。这些儿童表现出的行为和认知障碍模式，类似于在一些发育性自闭症样障碍中发现的模式，但也与成人额叶综合征中的模式相似。病情恶化可能是由于涉及额叶的异常长期癫痫功能障碍所致。这个过程可能是可逆的，似乎与后天性癫痫性失语症的假设相同，但定位不同。
