Child Development Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sci Rep. 2023 Aug 8;13(1):12882. doi: 10.1038/s41598-023-39984-9.
Slow waves are an electrophysiological characteristic of non-rapid eye movement sleep and a marker of the restorative function of sleep. In certain pathological conditions, such as different types of epilepsy, slow-wave sleep is affected by epileptiform discharges forming so-called "spike-waves". Previous evidence shows that the overnight change in slope of slow waves during sleep is impaired under these conditions. However, these past studies were performed in a small number of patients, considering only short segments of the recording night. Here, we screened a clinical data set of 39'179 pediatric EEG recordings acquired in the past 25 years (1994-2019) at the University Children's Hospital Zurich and identified 413 recordings of interest. We applied an automated approach based on machine learning to investigate the relationship between sleep and epileptic spikes in this large-scale data set. Our findings show that the overnight change in the slope of slow waves was correlated with the spike-wave index, indicating that the impairment of the net reduction in synaptic strength during sleep is spike dependent.
慢波是非快速眼动睡眠的一种电生理特征，也是睡眠恢复功能的标志物。在某些病理情况下，如不同类型的癫痫，慢波睡眠会受到形成所谓“棘波”的癫痫样放电的影响。先前的证据表明，在这些情况下，睡眠期间慢波斜率的夜间变化受损。然而，这些过去的研究是在少数患者中进行的，仅考虑了记录夜间的短片段。在这里，我们筛选了过去 25 年（1994-2019 年）在苏黎世大学儿童医院获得的 39179 份儿科脑电图记录的临床数据集，确定了 413 份感兴趣的记录。我们应用了一种基于机器学习的自动方法来研究这个大规模数据集中心律失常与癫痫棘波之间的关系。我们的研究结果表明，慢波斜率的夜间变化与棘波指数呈正相关，表明睡眠期间突触强度净减少的损害与棘波有关。
