Dotzer F, Gromer H
Medizinische Abteilung, Krankenhaus München-Perlach.
Fortschr Med. 1993 May 20;111(14):245-8.
Calcium antagonists reduce myocardial oxygen demand and increase the oxygen supply to the myocardium via a coronary dilating effect. For the treatment of silent myocardial ischämia and of stable and instable angina pectoris, studies with verapamil revealed an anti-ischemic efficacy comparable with that of beta blockers and nitrates. Studies of secondary prophylaxis after acute myocardial infarction reveal a cardioprotective effect of verapamil in terms of a reduction in mortality and re-infarction rates. Calcium antagonists have further organ-protective effects such as a reduction of left ventricular wall hypertrophy and a slowing effect on the progression of arteriosclerotic vascular changes.
钙拮抗剂可降低心肌需氧量，并通过冠状动脉扩张作用增加心肌的氧供应。对于无症状性心肌缺血以及稳定型和不稳定型心绞痛的治疗，使用维拉帕米的研究显示其抗缺血疗效与β受体阻滞剂和硝酸盐相当。急性心肌梗死后二级预防的研究表明，维拉帕米具有心脏保护作用，可降低死亡率和再梗死率。钙拮抗剂还具有进一步的器官保护作用，如减轻左心室壁肥厚以及减缓动脉硬化性血管病变的进展。
