用于体内耳蜗刺激的集总参数模型。

Lumped-parameter model for in vivo cochlear stimulation.

作者信息

Suesserman M F, Spelman F A

机构信息

Regional Primate Research Center, University of Washington, Seattle 98195.

出版信息

IEEE Trans Biomed Eng. 1993 Mar;40(3):237-45. doi: 10.1109/10.216407.

DOI:10.1109/10.216407

PMID:8335327

Abstract

This paper presents a lumped-parameter model that stimulates the in vivo electrical properties of a guinea pig cochlea implanted with a multielectrode stimulating array. A basic model of the low-frequency electroanatomy in a normally functioning guinea pig cochlea is developed by adding critical membrane capacitances to Strelioff's resistive network model [1]. The basic model of normal cochlear tissues is modified to account for anatomical and physiological differences between a normal and implanted cochlea, which results in an impedance model of an implanted cochlea. Simulating the results of in vivo cochlear stimulation verifies the accuracy with which the modified cochlear model represents electrical properties within an electrically stimulated cochlea. Generalized simulations using this model suggest a straightforward phasing scheme capable of achieving sharply focused, channel-independent multielectrode cochlear stimulation.

摘要

本文提出了一种集总参数模型，该模型可模拟植入多电极刺激阵列的豚鼠耳蜗的体内电学特性。通过在斯特雷利奥夫电阻网络模型[1]中添加关键膜电容，建立了正常功能豚鼠耳蜗低频电解剖学的基本模型。对正常耳蜗组织的基本模型进行修改，以考虑正常耳蜗与植入耳蜗之间的解剖学和生理学差异，从而得到植入耳蜗的阻抗模型。模拟体内耳蜗刺激的结果验证了修改后的耳蜗模型对电刺激耳蜗内电学特性的表征准确性。使用该模型进行的广义模拟提出了一种直接的相位方案，该方案能够实现尖锐聚焦、与通道无关的多电极耳蜗刺激。