一种一氧化氮（.NO）氧化剂咪唑啉氧基 N-氧化物对依赖一氧化氮的抗菌作用有显著增强。
Pronounced enhancement of .NO-dependent antimicrobial action by an .NO-oxidizing agent, imidazolineoxyl N-oxide.
作者信息
Yoshida K, Akaike T, Doi T, Sato K, Ijiri S, Suga M, Ando M, Maeda H
机构信息
Department of Microbiology, Kumamoto University School of Medicine, Japan.
出版信息
Infect Immun. 1993 Aug;61(8):3552-5. doi: 10.1128/iai.61.8.3552-3555.1993.
Abstract
The antimicrobial action of .NO against Cryptococcus neoformans was investigated by using imidazolineoxyl N-oxide, which we recently reported removes .NO via oxidation (T. Akaike, M. Yoshida, Y. Miyamoto, K. Sato, M. Kohno, K. Sasamoto, K. Miyazaki, S. Ueda, and H. Maeda, Biochemistry 32:827-832, 1993). No appreciable fungicidal activity was observed in neutral .NO solutions. Imidazolineoxyl N-oxide induced or enhanced fungicidal action in neutral or acidic .NO solutions, respectively. Our results provide convincing evidence that .NO is not a microbicidal molecular species.
摘要
我们使用咪唑啉氧基 N-氧化物研究了一氧化氮（.NO）对新型隐球菌的抗菌作用，我们最近报道该氧化物可通过氧化作用去除一氧化氮（赤池 T、吉田 M、宫本 Y、佐藤 K、小野 M、笹本 K、宫崎 K、上田 S、前田 H，《生物化学》32:827 - 832，1993 年）。在中性一氧化氮溶液中未观察到明显的杀菌活性。咪唑啉氧基 N-氧化物分别在中性或酸性一氧化氮溶液中诱导或增强了杀菌作用。我们的结果提供了令人信服的证据，表明一氧化氮不是一种杀菌分子种类。
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