黑色素化和非黑色素化新型隐球菌对氮源和氧源氧化剂的敏感性。
Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants.
作者信息
Wang Y, Casadevall A
机构信息
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
出版信息
Infect Immun. 1994 Jul;62(7):3004-7. doi: 10.1128/iai.62.7.3004-3007.1994.
Abstract
Melanized Cryptococcus neoformans cells were less susceptible than nonmelanized cells to the fungicidal effects of nitrogen- and oxygen-derived oxidants. The results support the hypothesis that the phenoloxidase enzyme system contributes to virulence by protecting C. neoformans against nitrogen- and oxygen-derived oxidative antimicrobial molecules produced by immune effector cells.
摘要
黑色素化的新型隐球菌细胞比未黑色素化的细胞对氮源和氧源氧化剂的杀菌作用更不敏感。这些结果支持了这样一种假说，即酚氧化酶系统通过保护新型隐球菌免受免疫效应细胞产生的氮源和氧源氧化抗菌分子的影响，从而有助于其毒力。
相似文献
1
Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants.黑色素化和非黑色素化新型隐球菌对氮源和氧源氧化剂的敏感性。
Infect Immun. 1994 Jul;62(7):3004-7. doi: 10.1128/iai.62.7.3004-3007.1994.
2
Different susceptibility of three clinically isolated strains of Cryptococcus neoformans to the fungicidal effects of reactive nitrogen and oxygen intermediates: possible relationships with virulence.
Microbiol Immunol. 1997;41(9):725-31. doi: 10.1111/j.1348-0421.1997.tb01917.x.
3
Cryptococcus neoformans melanin and virulence: mechanism of action.新型隐球菌黑色素与毒力：作用机制
Infect Immun. 1995 Aug;63(8):3131-6. doi: 10.1128/iai.63.8.3131-3136.1995.
4
Susceptibility of melanized and nonmelanized Cryptococcus neoformans to the melanin-binding compounds trifluoperazine and chloroquine.黑色素化和非黑色素化新型隐球菌对黑色素结合化合物三氟拉嗪和氯喹的敏感性。
Antimicrob Agents Chemother. 1996 Mar;40(3):541-5. doi: 10.1128/AAC.40.3.541.
5
Decreased susceptibility of melanized Cryptococcus neoformans to UV light.黑色素化新生隐球菌对紫外线的敏感性降低。
Appl Environ Microbiol. 1994 Oct;60(10):3864-6. doi: 10.1128/aem.60.10.3864-3866.1994.
6
Cryptococcus neoformans/Cryptococcus gattii species complex melanized by epinephrine: Increased yeast survival after amphotericin B exposure.肾上腺素诱导新生隐球菌/格特隐球菌复合种群黑色素化：两性霉素 B 暴露后酵母存活率增加。
Microb Pathog. 2020 Jun;143:104123. doi: 10.1016/j.micpath.2020.104123. Epub 2020 Mar 10.
7
Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin.新型隐球菌和荚膜组织胞浆菌的黑化会降低它们对两性霉素B和卡泊芬净的敏感性。
Antimicrob Agents Chemother. 2002 Nov;46(11):3394-400. doi: 10.1128/AAC.46.11.3394-3400.2002.
8
Effects of melanin upon susceptibility of Cryptococcus to antifungals.黑色素对新型隐球菌抗真菌药敏性的影响。
Microbiol Immunol. 2003;47(4):271-7. doi: 10.1111/j.1348-0421.2003.tb03395.x.
9
Effects of voriconazole on Cryptococcus neoformans.伏立康唑对新型隐球菌的作用。
Antimicrob Agents Chemother. 2004 Jun;48(6):2014-20. doi: 10.1128/AAC.48.6.2014-2020.2004.
10
Variability in UVB tolerances of melanized and nonmelanized cells of Cryptococcus neoformans and C. laurentii.新型隐球菌和罗伦隐球菌黑色素化及非黑色素化细胞对紫外线B耐受性的变异性
Photochem Photobiol. 2009 Jan-Feb;85(1):205-13. doi: 10.1111/j.1751-1097.2008.00418.x. Epub 2008 Aug 22.
引用本文的文献
1
Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell () Residues for Skin-Care Applications.负载有来自山核桃壳残渣的黑色素的电纺膜用于皮肤护理应用。
Membranes (Basel). 2025 Feb 3;15(2):44. doi: 10.3390/membranes15020044.
2
Integrative Proteome and Metabolomics Analyses of Cryptococcus neoformans Responses to Melanin Substrates Niger seed and L-DOPA.整合蛋白质组学和代谢组学分析新型隐球菌对黑色素底物黎豆和 L-DOPA 的响应。
Curr Microbiol. 2024 Nov 8;81(12):451. doi: 10.1007/s00284-024-03979-0.
3
United toward a common goal: Coordination of microbial virulence phenotypes.朝着共同目标团结协作：微生物毒力表型的协调
Proc Natl Acad Sci U S A. 2024 Oct 22;121(43):e2417587121. doi: 10.1073/pnas.2417587121. Epub 2024 Oct 14.
4
Cell wall melanin impedes growth of the polysaccharide capsule by sequestering calcium.细胞壁黑色素通过螯合钙来阻碍多糖荚膜的生长。
Proc Natl Acad Sci U S A. 2024 Sep 17;121(38):e2412534121. doi: 10.1073/pnas.2412534121. Epub 2024 Sep 11.
5
Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis.变形虫对隐球菌的捕食：偶然病原体假说的定量和群体基因组评估。
PLoS Pathog. 2023 Nov 13;19(11):e1011763. doi: 10.1371/journal.ppat.1011763. eCollection 2023 Nov.
6
An Alpha-Glucan from Mediates Fungal-Host Interaction Signaling through Dectin-1 and Mincle.一种来自[具体来源未提及]的α-葡聚糖通过脱铁素-1和小C型凝集素样受体介导真菌与宿主的相互作用信号传导。
J Fungi (Basel). 2023 Feb 23;9(3):291. doi: 10.3390/jof9030291.
7
Differentiated extracts from freshwater and terrestrial mollusks inhibit virulence factor production in Cryptococcus neoformans.淡水和陆生贝类的分化提取物抑制新型隐球菌毒力因子的产生。
Sci Rep. 2023 Mar 26;13(1):4928. doi: 10.1038/s41598-023-32140-3.
8
"Under Pressure" - How fungi evade, exploit, and modulate cells of the innate immune system.“承压之下”——真菌如何逃避、利用和调节先天免疫系统细胞。
Semin Immunol. 2023 Mar;66:101738. doi: 10.1016/j.smim.2023.101738. Epub 2023 Mar 4.
9
Melaninization Reduces Cryptococcus neoformans Susceptibility to Mechanical Stress.黑色素化降低新型隐球菌对机械压力的易感性。
mSphere. 2023 Feb 21;8(1):e0059122. doi: 10.1128/msphere.00591-22. Epub 2023 Jan 5.
10
Infection in the Central Nervous System: The Battle between Host and Pathogen.中枢神经系统感染：宿主与病原体之间的斗争
J Fungi (Basel). 2022 Oct 12;8(10):1069. doi: 10.3390/jof8101069.
本文引用的文献
1
Nonencapsulated Variant of Cryptococcus neoformans I. Virulence Studies and Characterization of Soluble Polysaccharide.新型隐球菌非包被变异株 I. 毒力研究及可溶性多糖的特性。
Infect Immun. 1971 Feb;3(2):287-94. doi: 10.1128/iai.3.2.287-294.1971.
2
On the origin of the free radical property of melanins.论黑色素自由基性质的起源。
Arch Biochem Biophys. 1960 Feb;86:231-2. doi: 10.1016/0003-9861(60)90410-0.
3
Pronounced enhancement of .NO-dependent antimicrobial action by an .NO-oxidizing agent, imidazolineoxyl N-oxide.一种一氧化氮（.NO）氧化剂咪唑啉氧基 N-氧化物对依赖一氧化氮的抗菌作用有显著增强。
Infect Immun. 1993 Aug;61(8):3552-5. doi: 10.1128/iai.61.8.3552-3555.1993.
4
Susceptibilities of serial Cryptococcus neoformans isolates from patients with recurrent cryptococcal meningitis to amphotericin B and fluconazole.复发性新型隐球菌性脑膜炎患者的系列新型隐球菌分离株对两性霉素B和氟康唑的敏感性
Antimicrob Agents Chemother. 1993 Jun;37(6):1383-6. doi: 10.1128/AAC.37.6.1383.
5
Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase.新型隐球菌双酚氧化酶的生化与分子特性：鉴定为漆酶
J Bacteriol. 1994 Feb;176(3):656-64. doi: 10.1128/jb.176.3.656-664.1994.
6
Antioxidant function of fungal melanin.真菌黑色素的抗氧化功能。
J Bacteriol. 1993 Nov;175(21):7102-4. doi: 10.1128/jb.175.21.7102-7104.1993.
7
Persistence of initial infection in recurrent Cryptococcus neoformans meningitis.复发性新型隐球菌脑膜炎初始感染的持续存在。
Lancet. 1993 Mar 6;341(8845):595-6. doi: 10.1016/0140-6736(93)90354-j.
8
Phenoloxidase activity and virulence in isogenic strains of Cryptococcus neoformans.新型隐球菌同基因菌株中的酚氧化酶活性与毒力
Infect Immun. 1982 Jun;36(3):1175-84. doi: 10.1128/iai.36.3.1175-1184.1982.
9
Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice.新型隐球菌缺乏黑色素的突变体及其对小鼠的毒力。
J Bacteriol. 1982 Jun;150(3):1414-21. doi: 10.1128/jb.150.3.1414-1421.1982.
10
Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans.新型隐球菌中酚氧化酶的生化研究及儿茶酚胺的利用
J Bacteriol. 1982 Jun;150(3):1212-20. doi: 10.1128/jb.150.3.1212-1220.1982.
Zotero 插件