营养不良和新生去神经支配小鼠肌肉中 T3 脱碘作用增强。

Increased T3 deiodination in dystrophic and neonatally denervated mouse muscle.

作者信息

De Jong J M, Van der Slooten E P, Den Hartog Jager W A

出版信息

J Neurol Sci. 1977 Jan-Feb;31(1):83-91. doi: 10.1016/0022-510x(77)90007-7.

Abstract

T3, free iodide levels and morphological features were compared in normal, 129 ReJ dy/dy dystrophic and neonatally denervated skeletal muscles of mice, killed 6 hr after a single intraperitoneal injection of iodine-labelled hormone. Both the dystrophic andthe denervated muscles were found to contain equal amounts of T3 but more iodide than the normal specimens. Increased iodide levels are considered to reflect augmented T3-catabolism by muscle dehalogenase and may indicate low free hormone levels in the soluble enzyme fraction of the cell, despite its normal overall T3 content. The close light-microscopic resemblance of 129 ReJ dy/dy dystrophy and neonatal denervation is confirmed. The possibility is discussed that one or several of the muscular dystrophies are forms of target organ hypothyroidism.

摘要

在单次腹腔注射碘标记激素6小时后处死的小鼠中，比较了正常、129 ReJ dy/dy营养不良和新生去神经支配的骨骼肌中的T3、游离碘水平和形态学特征。发现营养不良和去神经支配的肌肉中T3含量相等，但碘含量比正常标本更多。碘水平升高被认为反映了肌肉脱卤酶对T3分解代谢的增强，尽管细胞可溶性酶部分的总T3含量正常，但这可能表明游离激素水平较低。证实了129 ReJ dy/dy营养不良与新生去神经支配在光学显微镜下的相似性。讨论了一种或几种肌肉营养不良可能是靶器官甲状腺功能减退的形式。