（甲基 - ³H）二氯化十烃季铵掺入正常和营养不良小鼠肌肉的研究。
The study of (Methyl-3H)decamethonium dichloride incorporation into normal and dystrophic mouse muscle.
作者信息
Marusyk H, Monckton G
出版信息
J Physiol. 1976 Mar;256(1):159-65. doi: 10.1113/jphysiol.1976.sp011317.
Abstract
- (Methyl-3H)decamethonium dichloride was injected intravenously into the tail vein of dystrophic and normal mice of the Bar Harbour strain 129 ReJ/dy in paralysing doses. 2. Scintillation counts were made of 1 mm sections of diaphragm and tibialis anterior which showed a normal distribution of tritiated decamethonium in the dystrophic animals. 3. Intraperitoneal injections of L-(gamma-3H)leucine were made into dystrophic and normal mice. Examination of diaphragm and tibialis anterior by scintillation counting showed the abnormal uptake typical of dystrophic involvement of murine muscle. 4. The normal distribution of (methyl-3H)decamethonium dichloride uptake by the dystrophic muscle does not support the concept of active denervation in this disease.
摘要
- 将麻痹剂量的（甲基 - 3H）二氯十烃季铵静脉注射到巴港129 ReJ/dy品系的营养不良和正常小鼠的尾静脉中。2. 对膈肌和胫前肌的1毫米切片进行闪烁计数，结果显示在营养不良的动物中，氚化十烃季铵分布正常。3. 对营养不良和正常小鼠进行腹腔注射L - （γ - 3H）亮氨酸。通过闪烁计数对膈肌和胫前肌进行检查，结果显示出小鼠肌肉营养不良受累典型的异常摄取。4. 营养不良肌肉对（甲基 - 3H）二氯十烃季铵摄取的正常分布不支持该疾病中存在主动去神经支配的概念。
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