Miyasaki K, Takayoshi F
J Neuropathol Exp Neurol. 1977 Jan;36(1):1-8. doi: 10.1097/00005072-197701000-00002.
The patient, a clinical case of parkinsonism, was a 32-year-old man, born in 1942, long after the prevalence of von Economo's lethargic encephalitis in Japan. Anatomically, the neurons in the substantia nigra of the mid-brain were extensively degenerated, and presented Alzheimer's neurofibrillary tangles. At the same time, melanin pigment was scattered in the tissue and was phagocytized by glia cells. Perivascular cuffing was observed in the frontal lobe, parietal lobe, temporal lobe, hippocampus, and thalamus as well as in the substantia nigra. Neuronophagia was noted in the thalamic nuclei. The present case was believed to have parkinsonism not clinically or pathologically related to von Economo's encephalitis or to Japanese encephalitis, but following a mild encephalitis of unknown etiology.
该患者为帕金森综合征临床病例，是一名32岁男性，出生于1942年，远在日本嗜眠性脑炎流行之后。解剖学上，中脑黑质神经元广泛退化，并出现阿尔茨海默病神经原纤维缠结。同时，黑色素在组织中散在分布，并被神经胶质细胞吞噬。在额叶、顶叶、颞叶、海马体、丘脑以及黑质均观察到血管周围套袖现象。在丘脑核中发现噬神经元现象。本病例被认为患有帕金森综合征，在临床或病理上与嗜眠性脑炎或日本脑炎无关，而是继发于病因不明的轻度脑炎。
