Ishii T, Matsushita M, Hamada S
Acta Neuropathol. 1977 Jun 15;38(3):181-6. doi: 10.1007/BF00688063.
Characteristic residual (12-67 years) neuropathological features of 4 verified or suspected cases of Japanese B encephalitis (JBE) are reported. These features are summarized as: 1. unique distribution pattern of the main lesions, i.e. combination of lesions in the thalamus, substantia nigra and Ammon's horn. Lesions in the thalamus consistently involved, in a linear fashion, lamina medullaris medialis with nucleus intralaminalis and adjacent portions of the nucleus lateralis thalami. Lesions in the substantia nigra usually occupied the middle parts of zona compacta. These lesions were usually symmetrical, though unequal in extent. 2. Unique nature of the lesions, especially those in the thalamus and substantia nigra. Characteristic "light circumscribed foci (LCF)", which consisted of small rarefied areas, with few cellular and fibrous elements, surrounded by dense gliomesenchymal scarring, were observed there and occasionally in cerebral cortices. Lesions were thought to be vestiges of "circumscribed necrotic foci" reported in the CNS of acute stage of JBE. Additional characteristic features in the thalamic lesions were calcified and binucleated nerve cells. Alzheimer's neurofibrillary tangles were not found. Authors consider that the distribution and nature of the lesions are of diagnostic value.
报告了4例经证实或疑似日本乙型脑炎（JBE）患者（年龄12 - 67岁）的特征性残留神经病理学特征。这些特征总结如下：1. 主要病变的独特分布模式，即丘脑、黑质和海马角病变的组合。丘脑中的病变始终以线性方式累及内侧髓板及板内核以及丘脑外侧核的相邻部分。黑质中的病变通常占据致密带的中部。这些病变通常是对称的，尽管范围不等。2. 病变的独特性质，尤其是丘脑和黑质中的病变。在那里以及偶尔在大脑皮层中观察到特征性的“轻度局限性病灶（LCF）”，其由小的稀疏区域组成，细胞和纤维成分很少，周围有致密的胶质间充质瘢痕形成。这些病变被认为是JBE急性期中枢神经系统中报告的“局限性坏死灶”的遗迹。丘脑中病变的其他特征性表现为钙化和双核神经细胞。未发现阿尔茨海默病神经原纤维缠结。作者认为病变的分布和性质具有诊断价值。
