Huttunen J, Hömberg V, Lange H W
Neurological Therapy Center, University of Duesseldorf, FRG.
J Neurol Sci. 1993 Jun;116(2):119-24. doi: 10.1016/0022-510x(93)90315-p.
We recorded frontal, central and parietal somatosensory evoked potentials (SEPs) to median nerve stimulation in 20 patients with Huntington's disease (HD) and in a group of normal controls. Two stimulus repetition rates, 1 Hz and 5 Hz, were employed. In HD patients the early cortical potentials (latency range 20-30 ms) at all 3 recording locations were replaced by a widespread, broadly configured N20-25 deflection, while later potentials at 40-80 ms did not significantly differ from those of normals. In contrast to the early P22, P27 and N30 potentials in normals, the N20-25 potential in the patients was not significantly modified by changing the stimulus repetition rate. At 40-80 ms the stimulus rate effects were similar in the patients and normals. The results show that early pre- and postcentral SEPs are both pathological in HD, while later frontal and parietal components can be totally preserved. The early N20-25 in HD is possibly a subcortical potential, seen due to unmasking in the absence of early cortical deflections.
我们记录了20例亨廷顿病（HD）患者及一组正常对照者在正中神经刺激下的额、中央和顶叶体感诱发电位（SEP）。采用了1Hz和5Hz两种刺激重复率。在HD患者中，所有3个记录部位的早期皮质电位（潜伏期范围20 - 30ms）被广泛的、波形较宽的N20 - 25偏转所取代，而40 - 80ms的后期电位与正常对照者无显著差异。与正常对照者早期的P22、P27和N30电位不同，患者的N20 - 25电位在改变刺激重复率时无显著变化。在40 - 80ms时，患者和正常对照者的刺激率效应相似。结果表明，HD患者早期中央前和中央后SEP均存在病理改变，而后期的额部和顶叶成分可完全保留。HD患者早期的N20 - 25可能是一种皮质下电位，由于早期皮质偏转缺失而显现出来。
