Lambda light chain deposition disease presenting as an amyloid-like arthropathy.

We describe a case of lambda light chain deposition disease (LCDD) which presented with symmetric, seronegative, nonerosive arthritis associated with skin nodules and widespread, progressive soft tissue induration. Multiple biopsies disclosed Congo red nonbirefringent deposits which stained strongly with lambda light chain antiserum, allowing distinction from amyloid arthropathy. This is the first report of musculoskeletal involvement in LCDD.