Askew E W, Hecker A L, Wise W R
J Nutr. 1977 Jan;107(1):132-42. doi: 10.1093/jn/107.1.132.
Rats trained by 12 weeks of treadmill running were divided into two groups and fed a control diet or an identical diet supplemented with 0.5% L-carnitine. Adipose tissue fatty acid turnover was subsequently estimated by an odd-carbon fatty acid enrichment method utilizing undecanoate as a marker representative of adipose tissue fatty acids. Compared to sedentary untrained control rats, exercise training increased perirenal adipose tissue turnover rate approximately 70%. Trained rats fed the carnitine supplemented diet did not exhibit any further increase in turnover rate. Neither [1-14C]palmitate oxidation by skeletal muscle homogenates nor palmitycarnitine acyl-transferase activity in skeletal muscle mitochondria was affected by carnitine feeding. The results of this study indicate that exercise training increases the turnover rate of adipose tissue fatty acids, but supplemental dietary carnitine does not. Under the conditions of this study, endogenous skeletal muscle carnitine levels in trained rats appear to be adequate to support the rate of fatty acids oxidation incurred by daily treadmill running.
