Horimoto C, Yamaga S, Toba T, Tsujimura M
Department of Neurosurgery, Kitakyushu City Yahata Hospital, Japan.
No Shinkei Geka. 1993 Jun;21(6):509-12.
Six patients with massive hypertensive intracerebral hemorrhage and showing progression of consciousness-disturbance were treated by CT-guided stereotactic surgery. Serious complications or the age of these patients prevented evacuation of the hematomas by craniotomy under general anesthesia. The increase in the size of the intracerebral hematoma suggested by the progression of the consciousness-disturbance on admission was stopped by controlling the blood pressure. Stereotactic evacuation of the hematoma was performed using Komai's CT stereotactic apparatus 1-4 days after the onset. On the CT slice showing the maximum size of the hematoma, two target points showing each center or two circles which cover the greater part of the hematoma were determined, and then two drainage tubes were inserted into the two target points of the hematoma through two burr holes, and the hematoma was aspirated with a syringe. Postoperatively, every 12 hours, a solution of 60,000IU urokinase in 100 ml saline was irrigated into the hematoma cavity with aspiration of the hematoma, and finally 10 ml urokinase solution was left in the hematoma cavity. By 2-4 repetitions of this procedure, 83-91% of the estimated hematoma volume was evacuated using urokinase (120,000-240,000IU) for 1-2 days. Therefore, all of the cases showed improvement in the consciousness level without rebleeding or progression of serious complications. For large hypertensive intracerebral hematomas in aged patients or patients with serious complications, this stereotactic surgery can be carried out safely and rapidly through two drainage tubes using urokinase after 24 hours from the onset.
6例大量高血压性脑出血且意识障碍呈进行性加重的患者接受了CT引导下的立体定向手术治疗。这些患者的严重并发症或年龄因素使得无法在全身麻醉下通过开颅手术清除血肿。入院时意识障碍的进展提示脑内血肿增大,通过控制血压得以阻止。在发病后1 - 4天,使用小牧CT立体定向装置进行血肿的立体定向清除。在显示血肿最大尺寸的CT切片上,确定两个分别代表血肿中心的靶点或两个覆盖血肿大部分的圆圈,然后通过两个钻孔将两根引流管插入血肿的两个靶点,用注射器抽吸血肿。术后,每12小时将60000IU尿激酶溶于100ml生理盐水中注入血肿腔并抽吸血肿,最后在血肿腔内留置10ml尿激酶溶液。通过2 - 4次重复此操作,使用尿激酶(120000 - 240000IU)1 - 2天,清除了估计血肿体积的83 - 91%。因此,所有病例的意识水平均有改善,且无再出血或严重并发症进展。对于老年患者或有严重并发症的大型高血压性脑出血患者,发病24小时后可通过两根引流管安全、快速地进行这种立体定向手术,并使用尿激酶。