Pesonen E, Heldt G P, Merritt T A, Sahn D J, Elias W, Tikkanen I, Fyhrquist F, Andersson S
Department of Pediatrics, University of California Medical Center, San Diego.
Pediatr Pulmonol. 1993 Jun;15(6):362-4. doi: 10.1002/ppul.1950150609.
We studied the correlation of atrial natriuretic factor (ANF) with lung compliance in a series of 16 premature infants with respiratory distress syndrome (RDS). The infants were followed during the first week of life by sequential Doppler echocardiography, lung compliance, and ANF measurements. Plasma ANF concentration varied between 38 and 2220 pg/mL; mean concentrations of 393 and 123 pg/mL with the ductus open and with it closed, respectively (P < 0.01). The arteriolar/alveolar oxygen-tension ratio showed an inverse correlation with the logarithm (In) of the ANF concentration (r = -0.55, P = 0.0002). Both mean airway pressure and In ANF showed an inverse correlation with the arteriolar/alveolar oxygen tension ratio (R = -0.77, F = 20.5 and 13.8, respectively). Plasma ANF was inversely correlated to lung compliance (r = -0.64, P < 0.0001). In infants with RDS, plasma ANF concentrations increase with the severity of respiratory distress. Because ANF increases endothelial permeability, in this preliminary investigation lead to the hypothesis that it may contribute to respiratory distress by causing extravasation of fluid from the pulmonary circulation in these patients.
我们对16例患有呼吸窘迫综合征（RDS）的早产儿进行了研究，以探讨心房利钠因子（ANF）与肺顺应性之间的相关性。在这些婴儿出生后的第一周内，我们通过连续的多普勒超声心动图、肺顺应性和ANF测量对他们进行了跟踪观察。血浆ANF浓度在38至2220 pg/mL之间变化；动脉导管开放和关闭时的平均浓度分别为393和123 pg/mL（P < 0.01）。动脉/肺泡氧分压比与ANF浓度的对数（In）呈负相关（r = -0.55，P = 0.0002）。平均气道压力和In ANF与动脉/肺泡氧分压比均呈负相关（R分别为 -0.77和 -0.55，F分别为20.5和13.8）。血浆ANF与肺顺应性呈负相关（r = -0.64，P < 0.0001）。在患有RDS的婴儿中，血浆ANF浓度随呼吸窘迫的严重程度而增加。由于ANF会增加内皮通透性，在这项初步研究中得出一个假设，即它可能通过导致这些患者肺循环中的液体外渗而促使呼吸窘迫。
