Shaffer S G, Geer P G, Goetz K L
J Pediatr. 1986 Dec;109(6):1028-33. doi: 10.1016/s0022-3476(86)80294-3.
Atrial natriuretic factor (ANF) plasma concentrations were measured in 16 healthy term newborn infants and in 18 preterm infants with respiratory distress syndrome during the first 4 postnatal days. Changes in the plasma concentration of ANF were then correlated with postnatal age, severity of respiratory distress, and water and sodium balance. The plasma ANF concentration in healthy term infants increased during the first 2 days of life. Similar values were observed among preterm infants requiring hood oxygen. The plasma ANF concentrations were substantially higher in preterm infants receiving positive pressure ventilation. All infants had negative water and sodium balance during the period of study. No correlation was found, however, between absolute plasma ANF concentrations and urinary flow rate, sodium excretion, or fractional sodium excretion, suggesting that ANF did not exert a dominant role in the excretion of sodium in these infants.
在出生后的头4天内，对16名足月健康新生儿和18名患有呼吸窘迫综合征的早产儿的血浆心钠素（ANF）浓度进行了测量。然后将ANF的血浆浓度变化与出生后年龄、呼吸窘迫的严重程度以及水和钠平衡进行关联分析。足月健康婴儿的血浆ANF浓度在出生后的头2天内有所升高。在需要头罩吸氧的早产儿中也观察到了类似的值。接受正压通气的早产儿的血浆ANF浓度显著更高。在研究期间，所有婴儿的水和钠平衡均为负值。然而，在血浆ANF绝对浓度与尿流率、钠排泄或钠排泄分数之间未发现相关性，这表明ANF在这些婴儿的钠排泄中并未发挥主导作用。
