Degos L
Institut d'Hématologie, Hôpital Saint-Louis, Paris, France.
Nouv Rev Fr Hematol (1978). 1993 Jun;35(3):193-5.
All trans retinoic acid (ATRA) in the treatment of acute promyelocytic leukemia is the first model of differentiation therapy in malignancies, and represents the first strict correlation between a genetic defect and a specific treatment. In this disease the association of differentiating agents and chemotherapy gives much better results than each type of treatment (differentiating agent or chemotherapy).
全反式维甲酸（ATRA）用于治疗急性早幼粒细胞白血病是恶性肿瘤分化治疗的首个范例，并且代表了基因缺陷与特定治疗之间的首个严格关联。在这种疾病中，分化剂与化疗联合使用比每种单一治疗（分化剂或化疗）产生的效果要好得多。
