Skotnicki A B, Stoch A, Sacha T, Nowak W S
Kliniki Hematologii Collegium Medicum Uniwersytetu Jagiellońskiego, Krakowie.
Acta Haematol Pol. 1994;25(1):69-74.
A case of 62-year-old female with acute promyelocytic leukemia is presented, in whom in poor general condition, and with symptoms of severe haemorrhagic diathesis and biochemical signs of coagulopathy a treatment with trans-retinoic acid was induced. After three weeks of treatment with t-RA complete hematological and clinical remission was achieved, without bone marrow aplasia, worsening of hemostatic parameters, or necessity of protective or therapeutic antibiotics administration typical of conventional chemotherapy. Apart from skin allergization and increase of transaminases other side effects of the t-RA treatment were not observed.
报告了一例62岁急性早幼粒细胞白血病女性患者，该患者一般状况较差，有严重出血素质症状及凝血障碍的生化指标，遂采用全反式维甲酸进行诱导治疗。经全反式维甲酸治疗三周后，实现了完全血液学缓解和临床缓解，未出现骨髓抑制、止血参数恶化，也无需使用传统化疗典型的预防性或治疗性抗生素。除皮肤过敏和转氨酶升高外，未观察到全反式维甲酸治疗的其他副作用。
