Hajratwala B R, Dawson J E
J Pharm Sci. 1977 Jan;66(1):27-9. doi: 10.1002/jps.2600660106.
The kinetics of indomethacin degradation were followed in alkaline aqueous solutions at various temperatures between 20.1 and 40.7 degrees. The apparent first-order rate constants were evaluated from log absorbance versus time plots at lambda max 318 nm. The primary salt effect was positive. The rate constant-hydroxide-ion concentration profile was linear with a positive slope, suggesting the following rate law: kobs = k1 [OH-]. The experimental data fit the proposed reaction of degradation, I- + OH k1 leads to products, where I- = mono-dissociated indomethacin species. Activation energies and other related parameters were calculated from Arrhenius-type plots.
在20.1至40.7度之间的不同温度下，对碱性水溶液中吲哚美辛的降解动力学进行了跟踪。通过在318nm最大吸收波长处绘制吸光度对数与时间的关系图，评估了表观一级速率常数。一级盐效应为正。速率常数与氢氧根离子浓度的关系曲线呈线性，斜率为正，表明速率定律如下：kobs = k1 [OH-]。实验数据符合所提出的降解反应，即I- + OH k1 → 产物，其中I- = 单解离的吲哚美辛物种。根据阿仑尼乌斯型图计算了活化能和其他相关参数。
