Howes C A, Pullar T, Sourindhrin I, Mistra P C, Capel H, Lawson D H, Tilstone W J
Eur J Clin Pharmacol. 1983;24(1):99-102. doi: 10.1007/BF00613934.
Chronic administration of cimetidine was found to produce a fall in steady-state plasma concentrations of chlorpromazine and of indomethacin in patients. In each case there was some evidence of inhibition of metabolism, suggesting that the mechanism must therefore be decreased absorption sufficient to over-ride the metabolic change. This was confirmed by measurement of excretion of metabolites in the indomethacin study. The fall in indomethacin plasma concentrations was not associated with a change in the clinical effectiveness of the anti-inflammatory therapy.
研究发现，在患者中持续服用西咪替丁会导致氯丙嗪和吲哚美辛的稳态血浆浓度下降。在每种情况下，都有一些代谢抑制的证据，这表明其机制必然是吸收减少，足以抵消代谢变化。在吲哚美辛研究中，通过测量代谢物排泄证实了这一点。吲哚美辛血浆浓度的下降与抗炎治疗的临床疗效变化无关。
