Gill H S, Colditz I G, Watson D L
Department of Animal Science, University of New England, Armidale, New South Wales, Australia.
Res Vet Sci. 1993 May;54(3):361-5. doi: 10.1016/0034-5288(93)90136-4.
Several parameters of immune competence were measured in lambs with genetic resistance to Haemonchus contortus and in lambs with average susceptibility to H contortus (random-bred). Increase in skinfold thickness following intradermal injection was greater in resistant lambs for concanavalin A and to a lesser extent for phytohaemagglutinin. Both mitogens induced infiltration of superficial and deep dermis by eosinophils, CD4+, CD8+ and T19+ lymphocytes, though the responses did not differ between groups. Primary but not secondary antibody responses to the T cell-dependent antigen, ovalbumin was greater in resistant lambs. In contrast, antibody responses to the T cell-independent antigen, Brucella abortus lipopolysaccharide, did not differ between groups. Taken together the data suggest that enhanced T lymphocyte function may contribute to the greater resistance to H contortus of genetically resistant lambs.
对捻转血矛线虫具有遗传抗性的羔羊以及对捻转血矛线虫具有平均易感性的羔羊（随机 bred）的几种免疫能力参数进行了测量。皮内注射后，对伴刀豆球蛋白 A，抗性羔羊的皮肤褶皱厚度增加更大，对植物血凝素的增加幅度较小。两种丝裂原均诱导嗜酸性粒细胞、CD4⁺、CD8⁺ 和 T19⁺ 淋巴细胞浸润浅真皮和深真皮，尽管两组之间的反应没有差异。对 T 细胞依赖性抗原卵清蛋白的初次而非二次抗体反应在抗性羔羊中更强。相比之下，对 T 细胞非依赖性抗原流产布鲁氏菌脂多糖的抗体反应在两组之间没有差异。综合这些数据表明，增强的 T 淋巴细胞功能可能有助于遗传抗性羔羊对捻转血矛线虫的更大抗性。
