Valencia M, Randazzo L, Tapias G, Granel C, Olivé A
Unitat d'Al.lèrgia, Hospital Sant Pau, Barcelona.
Allergol Immunopathol (Madr). 1993 Mar-Apr;21(2):84-7.
The diagnosis of Alternaria allergy is difficult and tests in vivo and in vitro usually do not give results as satisfactory as those obtained with other allergens. We studied 33 patients with a cutaneous response of 2 mm2 or more to skin-prick tests for Alternaria (extract containing 104 micrograms/ml of Alt-1). Results were compared with those of RAST. Skin tests were positive in 75.8% of cases (the resulting papule was the same size as or larger than that elicited by 10 mg/ml histamine) and negative in 24.2% of cases. RAST was positive in 75% of cases and negative in 25%. There was no significant difference in the frequencies. RAST was positive four times more often in males than in females; when these figures were corrected for population data, the ratio was 2:1. The coefficient of correlation between the intensity of skin-test and RAST results was r = 0.51 (p < 0.05). These findings are evaluated and results are discussed.
链格孢属过敏的诊断较为困难，体内和体外试验通常无法给出像针对其他过敏原那样令人满意的结果。我们研究了33例对链格孢属皮肤点刺试验（含104微克/毫升Alt-1提取物）有2平方毫米或更大皮肤反应的患者。将结果与放射变应原吸附试验（RAST）的结果进行比较。皮肤试验75.8%的病例呈阳性（产生的丘疹与10毫克/毫升组胺引起的丘疹大小相同或更大），24.2%的病例呈阴性。RAST 75%的病例呈阳性，25%呈阴性。频率上无显著差异。RAST在男性中的阳性率是女性的四倍；根据人口数据校正这些数字后，比例为2:1。皮肤试验强度与RAST结果之间的相关系数为r = 0.51（p < 0.05）。对这些发现进行了评估并讨论了结果。
