Geschwind H J, Kvasnicka J, Dubois-Randé J L, Nakamura F
Unité d'hémodynamique et de cardiologie interventionnelle, CHU Henri-Mondor, Créteil.
Arch Mal Coeur Vaiss. 1993 Jan;86(1):87-95.
Laser angioplasty can now be performed on the coronary arteries as sources of pulsed laser and steerable multifibre catheters have become available. The aim of this study was to analyse the immediate results, the outcome and secondary effects of coronary angioplasty with excimer and holmium YAG laser. The homium-YAG laser was used in 40 patients (Group I) and the excimer laser in 46 patients (Group II). The immediate success rates were 55% in Group I and 71.7% in Group II. The highest success rates were obtained in lesions of saphenous vein grafts. The primary success rate was remarkably high in calcific lesions and complete occlusions. It was less impressive in long than in short stenoses in Group I. Treatment by laser coronary angioplasty alone was successful in 21.7% of patients in Group II and 5.0% of patients in Group I (p < 0.05). The failures were related to difficulty in reading the lesion, in passing the stenosis or in obtaining a reduction of its severity. The failures were more common in Group I (45%) than in Group II (28.3%). In this preliminary series there were no deaths, myocardial infarcts or emergency coronary bypass procedures. The following complications were observed: acute occlusions in 17.1% of patients in Group I and 7.5% of patients in Group II; spasm (10-13%); coronary dissection was commoner in Group II (28.3%) than in Group I (7.5%, p < 0.04). Angiographic and clinical follow-up at 6 months showed a restenosis rate of 46% in Group I and 43% in Group II.(ABSTRACT TRUNCATED AT 250 WORDS)
由于脉冲激光源和可操纵多光纤导管已可获得,现在可以对冠状动脉进行激光血管成形术。本研究的目的是分析准分子激光和钬钇铝石榴石激光冠状动脉血管成形术的即时结果、结局及继发效应。40例患者(I组)使用钬钇铝石榴石激光,46例患者(II组)使用准分子激光。I组即时成功率为55%,II组为71.7%。大隐静脉移植血管病变的成功率最高。钙化病变和完全闭塞的初次成功率非常高。I组中长狭窄的成功率不如短狭窄令人印象深刻。单独采用激光冠状动脉血管成形术治疗时,II组21.7%的患者和I组5.0%的患者治疗成功(p<0.05)。失败与病变识别困难、通过狭窄困难或狭窄严重程度降低未达目标有关。I组(45%)的失败比II组(28.3%)更常见。在这个初步系列研究中,没有死亡、心肌梗死或急诊冠状动脉搭桥手术。观察到以下并发症:I组17.1%的患者和II组7.5%的患者出现急性闭塞;痉挛(10 - 13%);冠状动脉夹层在II组(28.3%)比I组(7.5%,p<0.04)更常见。6个月时的血管造影和临床随访显示,I组再狭窄率为46%,II组为43%。(摘要截短于250词)