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[准分子激光辅助血管成形术。治疗复杂冠状动脉病变的即时结果]

[Excimer laser assisted angioplasty. Immediate results in the treatment of complex coronary lesions].

作者信息

Escojido H, Boyer C, Nebunu J C, Bouharaoua A, Collet F, Rossi P

机构信息

Centre de cardiologie interventionnelle, clinique Clairval, Marseille.

出版信息

Arch Mal Coeur Vaiss. 1996 Apr;89(4):407-15.

PMID:8762999
Abstract

Transluminal coronary angioplasty (TCA) with pulsed excimer laser (CVX 300 Spectranetics) was performed in 89 patients (age 63.7 years); CCS I: 6; CCS II: 12; CCS III: 40; CCS IV: 31; instable: 58%. There was a previous history of myocardial infarction (MI) in 27 cases, TCA (9 restenoses) in 24 cases, 19 bypass graft procedures, 13 failures of TCA. The lesions (n = 90) affected the left main coronary artery: 1 case; the left anterior descending artery: 37 cases; the left circumflex: 8 cases; the right coronary: 28 cases and there were saphenous vein grafts in 16 cases. The lesions were classified B2 (ACC/AHA) in 56 cases and type C in 34 cases. There were 24 lesions > 10 mm, 15 > 20 mm; calcification in 49 cases; excentric in 65 cases; ostial in 9 cases; affecting bifurcations in 13 cases; affecting collateral vessels in 16 cases; chronic occlusions in 12 cases and restenoses of stents in 4 cases. Multifiber catheters: 1.4 mm (50), 1.7 mm (41) and 2 mm (3), were used to deliver energies of 43.3 mj/m2 (+/- 8.1 mj) with an average of 5.2 +/- 1.2 applications persite, and 2.7 +/- 1.1 passages. A balloon dilatation was performed after laser angioplasty in 96% of cases. The following results were observed: success of laser angioplasty (20% reduction of stenosis) in 95.5%, a successful procedure (residual stenosis less than 50% without major complications) in 95.5%, and a clinical success (no pathological Q wave or non-Q wave infarction, bypass graft, or repeat TCA): 92.1%. The following complications were observed: death = 0, non-Q wave infarction 2.2%, emergency bypass surgery in 1 case with Q wave infarction: 1.1%. The use of laser angioplasty may be proposed in the following indications: long, moderately calcified lesion, ostial lesions, complete occlusions, bypass graft disease, failure of angioplasty. In addition to these indications, we propose the treatment of restenosis on stents. The main disadvantage of the Excimer Laser is the poor cost/benefit ratio, given the relatively small number of indications.

摘要

对89例患者(年龄63.7岁)进行了脉冲准分子激光(CVX 300 Spectranetics)腔内冠状动脉成形术(TCA);加拿大心血管学会(CCS)分级I级:6例;II级:12例;III级:40例;IV级:31例;不稳定型:58%。27例有心肌梗死(MI)病史,24例有TCA史(9例再狭窄),19例接受过搭桥手术,13例TCA失败。病变(n = 90)累及左主干冠状动脉:1例;左前降支:37例;左旋支:8例;右冠状动脉:28例,16例有大隐静脉移植血管。病变按美国心脏病学会/美国心脏协会(ACC/AHA)分类为B2级56例,C型34例。有24处病变> 10 mm,15处> 20 mm;49例有钙化;65例为偏心性病变;9例为开口处病变;13例累及分叉处;16例累及侧支血管;12例为慢性闭塞,4例为支架再狭窄。使用多光纤导管:1.4 mm(50根)、1.7 mm(41根)和2 mm(3根),输送能量为43.3 mj/m2(±8.1 mj),平均每部位应用5.2±1.2次,通过2.7±1.1次。96%的病例在激光血管成形术后进行了球囊扩张。观察到以下结果:激光血管成形术成功(狭窄减少20%)率为95.5%,手术成功(残余狭窄小于50%且无严重并发症)率为95.5%,临床成功(无病理性Q波或非Q波梗死、搭桥手术或再次TCA)率为92.1%。观察到以下并发症:死亡=0,非Q波梗死2.2%,1例Q波梗死患者进行急诊搭桥手术:1.1%。在以下情况下可考虑使用激光血管成形术:长段、中度钙化病变、开口处病变、完全闭塞、搭桥移植血管病变、血管成形术失败。除这些情况外,我们建议对支架再狭窄进行治疗。鉴于适应证相对较少,准分子激光的主要缺点是成本效益比不佳。

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