Damm G, Mizuguchi K, Bozeman R, Akkerman J, Aber G, Svejkovsky P, Takatani S, Nosé Y, Noon G P, DeBakey M E
Department of Surgery, Baylor College of Medicine, Houston, TX 77030.
Artif Organs. 1993 Jul;17(7):609-13. doi: 10.1111/j.1525-1594.1993.tb00603.x.
A cooperative effort between Baylor College of Medicine and NASA/Johnson Space Center is under way to develop an implantable axial flow left ventricular assist device (LVAD). The pump is intended as an assist device for either pulmonary or systemic circulatory support for more than 3 months' duration. Currently, in vitro studies are under way to reduce the hemolysis generated by the axial flow pump. A system utilizing a testing matrix has been developed to analyze the effects of different pump parameters on hemolysis. The following parameters are being investigated: impeller blade tip geometry, impeller/flow tube clearance, impeller/stator clearance, number of impeller blades, number of stator blades, and length of the impeller. To date, an index of hemolysis of 0.038 g/100 L has been achieved. The test matrix is not complete, and further improvements are expected.
贝勒医学院与美国国家航空航天局/约翰逊航天中心正在通力合作，研发一种可植入式轴流左心室辅助装置（LVAD）。该泵旨在作为一种辅助装置，用于肺循环或体循环支持，持续时间超过3个月。目前，正在进行体外研究，以减少轴流泵产生的溶血现象。已开发出一种利用测试矩阵的系统，以分析不同泵参数对溶血的影响。正在研究以下参数：叶轮叶片尖端几何形状、叶轮/流管间隙、叶轮/定子间隙、叶轮叶片数量、定子叶片数量以及叶轮长度。迄今为止，已实现的溶血指数为0.038 g/100 L。测试矩阵尚未完成，预计会有进一步改进。
