Gu Y J, Obster R, Haan J, Gallandat Huet R C, Eijgelaar A, van Oeveren W
University Hospital, Groningen, The Netherlands.
Artif Organs. 1993 Jul;17(7):660-5. doi: 10.1111/j.1525-1594.1993.tb00611.x.
To evaluate the biocompatibility and the efficacy of leukocyte removal filters, we performed a prospective study by using the cardiopulmonary bypass perfusate taken from the heart-lung machine for 20 patients who underwent cardiac surgery and were randomly divided into four groups according to the filters used. A leukocyte removal filter was installed in the transfusion line while the perfusate was transfused to the patients. No increases of C3a, C5a, elastase, and thromboxane were found during leukocyte filtration by polyester filters (Optima, Sepacell R500, and Pall RC100). Activation of the complement cascade was observed during filtration by the cellulose acetate filter (Cellselect) although the efficacy of the Cellselect filter was evidently higher than that of the polyester filter. These results imply that polyester leukocyte filters are superior to cellulose acetate filters in terms of biocompatibility but have a reduced efficacy. An optimal leukocyte filter providing both high efficacy and biocompatibility has yet to be developed.
为评估白细胞滤除器的生物相容性和效能，我们进行了一项前瞻性研究，使用从心肺机采集的体外循环灌注液，研究对象为20例接受心脏手术的患者，这些患者根据所使用的滤器随机分为四组。在向患者输注灌注液时，在输血管道中安装白细胞滤除器。在用聚酯滤器（Optima、Sepacell R500和Pall RC100）进行白细胞过滤期间，未发现C3a、C5a、弹性蛋白酶和血栓素增加。在用醋酸纤维素滤器（Cellselect）过滤期间观察到补体级联的激活，尽管Cellselect滤器的效能明显高于聚酯滤器。这些结果表明，聚酯白细胞滤器在生物相容性方面优于醋酸纤维素滤器，但效能较低。尚未开发出一种兼具高效能和生物相容性的最佳白细胞滤器。
