用放射性氯化铈诱导大鼠鼻窦癌

Induction in rats of paranasal sinus carcinomas with radioactive cerium chloride.

作者信息

Jasmin J R, Brocheriou C, Klein B, Morin M, Smadja-Joffe F, Cernea P, Jasmin C

出版信息

J Natl Cancer Inst. 1977 Feb;58(2):423-7. doi: 10.1093/jnci/58.2.423.

DOI:10.1093/jnci/58.2.423

Abstract

A colloidal suspension of radioactive cerium stabilized in the form of hydroxide was inoculated into young Sprague-Dawley rats near the maxillary sinus. Well-differentiated epidermoid carcinomas of the paranasal sinus were obtained in 8 of 12 rats and in 8 of 9 animals that liver more then 200 days. Therefore, this istope was highly effectivein inducing tumors at the site of injection. The uniformity of the histologic type of tumors induced under these experimental conditions was remarkable.

摘要

一种以氢氧化铈形式稳定存在的放射性铈胶体悬浮液被接种到接近上颌窦的幼年斯普拉格-道利大鼠体内。12只大鼠中有8只以及存活超过200天的9只动物中的8只患上了高分化的鼻窦表皮样癌。因此，这种同位素在注射部位诱导肿瘤方面非常有效。在这些实验条件下诱导产生的肿瘤组织学类型的一致性非常显著。