由磷-32作为胶体化合物诱发的放射性肿瘤。

Radioactive-induced tumors by phosphorus-32 as colloidal compound.

作者信息

Ubios A M, Silberman F S, Cabrini R L

出版信息

Cancer. 1983 May 1;51(9):1605-9. doi: 10.1002/1097-0142(19830501)51:9<1605::aid-cncr2820510909>3.0.co;2-2.

DOI:10.1002/1097-0142(19830501)51:9<1605::aid-cncr2820510909>3.0.co;2-2

Abstract

Chromic colloidal phosphate labeled with 32P, which has been proposed for the treatment of several articular diseases, was injected intra-articularly in the knee joint of adult Wistar rats. After a 270 days minimum latent period, tumors began to appear in the injected zone, to a 70% frequency. Ten lung metastases were detected. In five cases, squamous cell carcinomas were induced in the injected area. The relevance of a sound evaluation of the risk involved in treatments with radioactive isotopes, is discussed.

摘要

已被提议用于治疗多种关节疾病的32P标记的铬胶体磷酸盐，被注射到成年Wistar大鼠的膝关节内。在最短270天的潜伏期后，肿瘤开始在注射区域出现，出现频率为70%。检测到10处肺转移。在5例中，注射区域诱发了鳞状细胞癌。本文讨论了对放射性同位素治疗所涉及风险进行合理评估的相关性。