亚胺培南-西司他丁在奇异柠檬酸杆菌引起的新生儿脑膜炎中的应用。

The use of imipenem-cilastatin in neonatal meningitis caused by Citrobacter diversus.

作者信息

Haimi-Cohen Y, Amir J, Weinstock A, Varsano I

机构信息

Department of Pediatrics, Golda Medical Center, Hasharon Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tiqva, Israel.

出版信息

Acta Paediatr. 1993 Jun-Jul;82(6-7):530-2. doi: 10.1111/j.1651-2227.1993.tb12744.x.

DOI:10.1111/j.1651-2227.1993.tb12744.x

PMID:8338984

Abstract

Citrobacter diversus is a cause of severe meningitis in neonates and infants. It is unique in its propensity to produce brain abscesses that play an important role in the poor prognosis associated with this condition. The recommended therapeutic regimen of third-generation cephalosporines, aminoglycosides and trimethoprim-sulfamethoxazole is usually disappointing. We describe the use of imipenemcilastatin in successfully treating Citrobacter diversus meningitis complicated by brain abscesses.

摘要

奇异柠檬酸杆菌是新生儿和婴儿严重脑膜炎的病因之一。它的独特之处在于易于形成脑脓肿，而脑脓肿在该病症相关的不良预后中起重要作用。推荐使用的第三代头孢菌素、氨基糖苷类药物和甲氧苄啶 - 磺胺甲恶唑的治疗方案通常效果不佳。我们描述了使用亚胺培南 - 西司他丁成功治疗合并脑脓肿的奇异柠檬酸杆菌脑膜炎的情况。