Frick T W, Speiser D E, Bimmler D, Largiadèr F
Department of Surgery, University Hospital, Zürich, Switzerland.
Dig Dis. 1993;11(2):113-32. doi: 10.1159/000171405.
A comprehensive literature search was performed to collect all available data on drug-induced pancreatitis. Strong evidence for an association with acute pancreatitis has been described for anticholinesterases, calcium 2',3'-dideoxyinosine, estrogen, L-asparaginase, salicylates, thiazide-diuretics, valproic acid, and vinca alkaloids. Weak evidence has been found for antituberculous agents, azathioprine, biguanides, cisplatinum, cyclosporine A, H2-blocking agents, loop diuretics, 6-mercaptopurine, metronidazole, pentamidine, steroids, sulfonamides, sulindac and tetracycline. Many cases were associated with underlying conditions known to induce acute pancreatitis themselves. It is concluded that for none of the drugs studied the available data are consistent enough to support a definite association with acute pancreatitis. Nevertheless, the data suggest that drugs may be a trigger or a cofactor in inducing pancreatitis.
进行了全面的文献检索，以收集所有关于药物性胰腺炎的可用数据。已描述了抗胆碱酯酶、2',3'-二脱氧肌苷、雌激素、L-天冬酰胺酶、水杨酸盐、噻嗪类利尿剂、丙戊酸和长春花生物碱与急性胰腺炎相关的有力证据。已发现抗结核药、硫唑嘌呤、双胍类、顺铂、环孢素A、H2阻滞剂、袢利尿剂、6-巯基嘌呤、甲硝唑、喷他脒、类固醇、磺胺类、舒林酸和四环素的相关证据较弱。许多病例与已知本身可诱发急性胰腺炎的基础疾病有关。结论是，对于所研究的任何药物，现有数据都不足以一致支持与急性胰腺炎有明确关联。然而，数据表明药物可能是诱发胰腺炎的触发因素或辅助因素。
