Rünzi M, Layer P
Department of Medicine, University of Essen, Germany.
Pancreas. 1996 Jul;13(1):100-9. doi: 10.1097/00006676-199607000-00014.
In the past, numerous reports on drugs probably causing acute pancreatitis have been published. However, most of these case reports were anecdotal with a lack of obvious evidence and did not present a comprehensive summary. Although drug-associated pancreatitis is rare, it is gaining increasing importance with the introduction of several potent new agents, i.e., anti-acquired immunodeficiency syndrome drugs. The following comprehensive review scrutinizes the evidence present in the world literature on drugs associated with acute or chronic pancreatitis and, based on this, categorizes in a definite, probable, or possible causality. In addition, explanations for the pathophysiological mechanisms are discussed.
过去，已经发表了许多关于可能导致急性胰腺炎的药物的报告。然而，这些病例报告大多是轶事性的，缺乏明显的证据，也没有进行全面的总结。虽然药物相关性胰腺炎很少见，但随着几种强效新药（即抗获得性免疫缺陷综合征药物）的引入，其重要性日益增加。以下综合综述审视了世界文献中有关与急性或慢性胰腺炎相关药物的证据，并据此将因果关系分为明确、很可能或可能三类。此外，还讨论了病理生理机制的解释。
