Frassica F J, Gorski J P, Pritchard D J, Sim F H, Chao E Y
Department of Orthopaedics, Mayo Clinic/Mayo Foundation, Rochester, Minnesota 55905.
Clin Orthop Relat Res. 1993 Aug(293):378-90.
A comparative analysis was made of subchondral replacement with polymethylmethacrylate and autogeneic bone grafts in defects in the medial femoral condyles of dogs. The defect produced a 50% reduction in subchondral stiffness. An in vitro preparation helped establish that subchondral stiffness returned to normal after reconstruction with polymethylmethacrylate. The in vivo model demonstrated a reduction in subchondral stiffness in both groups at three weeks, but the bone grafted side returned to normal and the methylmethacrylate side recovered to 79% of the control at 12 weeks. There were no deleterious effects on the articular cartilage in either group when analyzed histologically and biochemically. A marked increase in new bone formation and subchondral porosity was found in the polymethylmethacrylate groups. This study supports the clinical use of subchondral polymethylmethacrylate after the exteriorization and curettage of benign bone tumors such as giant cell tumors.
对犬股骨内侧髁缺损采用聚甲基丙烯酸甲酯和自体骨移植进行软骨下置换的情况进行了比较分析。该缺损使软骨下硬度降低了50%。体外制备有助于确定用聚甲基丙烯酸甲酯重建后软骨下硬度恢复正常。体内模型显示，两组在三周时软骨下硬度均降低，但植骨侧在12周时恢复正常，聚甲基丙烯酸甲酯侧恢复至对照的79%。组织学和生化分析显示，两组对关节软骨均无有害影响。聚甲基丙烯酸甲酯组新骨形成和软骨下孔隙率显著增加。本研究支持在切除和刮除良性骨肿瘤（如骨巨细胞瘤）后临床应用软骨下聚甲基丙烯酸甲酯。
