Mente P L, Lewis J L
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois.
J Orthop Res. 1994 Sep;12(5):637-47. doi: 10.1002/jor.1100120506.
The elastic moduli of calcified cartilage and subchondral bone tissues were measured experimentally with use of a three-point bending test. Specimens were obtained from a bovine patella and the distal end of a bovine femur, from two different animals. Fifteen specimens were tested as "pure" subchondral bone beams, and 15 were tested as composite calcified cartilage/subchondral bone beams. A least-squares optimization scheme was used to obtain modulus values from the composite beams. The elastic modulus for subchondral bone calculated from the "pure" subchondral bone beams was 2.3 +/- 1.5 GPa (3.9 +/- 1.5 GPa for specimens from the femur and 1.6 +/- 0.7 GPa for specimens from the patella). The composite beam optimization resulted in a modulus for subchondral bone of 5.7 +/- 1.9 GPa and a modulus for calcified cartilage of 0.32 +/- 0.25 GPa. The modulus for the calcified cartilage was more than an order of magnitude lower than the modulus of the underlying subchondral bone. This supports the idea that the zone of calcified cartilage forms a transitional zone of intermediate stiffness between the articular cartilage and the subchondral bone.
采用三点弯曲试验对钙化软骨和软骨下骨组织的弹性模量进行了实验测量。标本取自两头不同动物的牛髌骨和牛股骨远端。15个标本作为“纯”软骨下骨梁进行测试，15个作为复合钙化软骨/软骨下骨梁进行测试。采用最小二乘优化方案从复合梁中获取模量值。由“纯”软骨下骨梁计算得出的软骨下骨弹性模量为2.3±1.5 GPa（股骨标本为3.9±1.5 GPa，髌骨标本为1.6±0.7 GPa）。复合梁优化得出软骨下骨模量为5.7±1.9 GPa，钙化软骨模量为0.32±0.25 GPa。钙化软骨的模量比其下方软骨下骨的模量低一个数量级以上。这支持了钙化软骨区域在关节软骨和软骨下骨之间形成中等硬度过渡区的观点。
