Geerards A J, Kok J H
Department of Ophthalmology, University of Amsterdam, The Netherlands.
Cornea. 1993 Jul;12(4):277-81. doi: 10.1097/00003226-199307000-00001.
Many investigators have measured corneal thickness after keratoplasty using organ culture and storage mediums. Values for corneal thickness were found to stabilize 6-12 months postoperatively, reaching normal values. We followed 59 corneal transplant recipients whose donor tissue was obtained from organ culture (average preservation time 13 days) for > 1 year retrospectively. The overall graft survival was 95.3%. The graft was thick in the early postoperative period. It subsequently became thinner, reaching the lowest level 5-9 months postoperatively (mean 0.48 mm, SD 0.04). After this period the corneas gradually became thicker and reached the normal corneal thickness. The extreme thinning of transplanted corneas in the first postoperative year has not been described before. We found a negative correlation between conservation time and thickness 5-9 months postoperatively. We postulate that organ culture may have a high impact on keratocyte function.
许多研究者使用器官培养和储存介质测量了角膜移植术后的角膜厚度。发现角膜厚度值在术后6 - 12个月稳定下来，达到正常数值。我们回顾性地随访了59例角膜移植受者，其供体组织取自器官培养（平均保存时间13天），随访时间超过1年。总体移植物存活率为95.3%。移植物在术后早期较厚。随后变薄，在术后5 - 9个月达到最薄水平（平均0.48毫米，标准差0.04）。在此之后，角膜逐渐变厚并达到正常角膜厚度。移植角膜在术后第一年的极度变薄情况此前未曾有过描述。我们发现术后5 - 9个月时保存时间与厚度之间呈负相关。我们推测器官培养可能对角膜细胞功能有很大影响。
