Skromne-Kadlubik G, Valdez E G, Férez A, Medina M, Celis C
J Urol. 1977 Feb;117(2):225-6. doi: 10.1016/s0022-5347(17)58409-8.
The nerve growth factor is a polypeptide isolated from the salivary glands of certain laboratory animals. Its greatest physiological effect is on the autonomic nervous system. When antiserum against this nerve growth factor was injected in newborn animals nearly total destruction of the sympathetic ganglia was noted, a procedure known as immunosympathectomy. The anti-nerve growth factor labeled with 131iodine was injected in rats to determine organ distribution at different intervals (2, 4, 6, 8 and 24 hours). A selective concentration was obtained in the sympathetic ganglia and adrenal medulla (adrenal ganglia) 4 hours after the intravenous injection of 50 muCi. 131Iodine anti-nerve growth factor, with a specific activity of 0.001 gm. per mCi., permitted scanning of this structure for the first time. No intolerance or radiotoxicity has been observed in the animals and the results are encouraging. Radioimmunoscanning of the sympathetic ganglia and adrenal medulla in the human and radioimmunosympathectomy of the structures are being studied currently and will be subjects of future communications.
神经生长因子是从某些实验动物的唾液腺中分离出来的一种多肽。它最大的生理作用是作用于自主神经系统。当将抗这种神经生长因子的抗血清注射到新生动物体内时，可观察到交感神经节几乎完全被破坏，这一过程称为免疫交感神经切除术。将用131碘标记的抗神经生长因子注射到大鼠体内，以确定在不同时间间隔（2、4、6、8和24小时）的器官分布情况。静脉注射50微居里后4小时，在交感神经节和肾上腺髓质（肾上腺神经节）中获得了选择性浓集。比活度为每毫居里0.001克的131碘抗神经生长因子首次使对该结构的扫描成为可能。在动物身上未观察到不耐受或放射毒性，结果令人鼓舞。目前正在研究人体交感神经节和肾上腺髓质的放射免疫扫描以及这些结构的放射免疫交感神经切除术，它们将是未来通讯的主题。
