在角叉菜胶和酵母聚糖诱导的大鼠胸膜炎期间，细胞相关的和可溶性磷脂酶A2增加。

Cell-associated and soluble phospholipases A2 increase during carrageenan and zymosan-induced pleurisy in rat.

作者信息

Tesson F, Ruffié C, Hidi R, e Silva P M, Vazeux G, Vargaftig B B, Bon C

机构信息

Unités des Venins et de Pharmacologie Cellulaire, Unité Associée Institut Pasteur/INSERM U-285, Paris, France.

出版信息

Eur J Pharmacol. 1993 Jun 1;248(1):27-32. doi: 10.1016/0926-6917(93)90021-h.

DOI:10.1016/0926-6917(93)90021-h

PMID:8339752

Abstract

Extra-cellular and cell-associated Ca(2+)-dependent phospholipases A2 and released thromboxane B2 were correlated to exudation and cell migration during rat pleurisy induced by carrageenan or zymosan. Extra-cellular phospholipase A2 was delayed with respect to acute inflammation, while cell-associated phospholipase A2 closely correlated with cell migration and thromboxane B2 levels. This confirms that the subcellular localization of phospholipases A2 is linked to their physiological action and, in particular, suggests that the cell-associated, rather than the extracellular enzyme, accounts for the production of eicosanoids.

摘要

在角叉菜胶或酵母聚糖诱导的大鼠胸膜炎期间，细胞外和细胞相关的钙依赖性磷脂酶A2以及释放的血栓素B2与渗出和细胞迁移相关。细胞外磷脂酶A2在急性炎症方面出现延迟，而细胞相关的磷脂酶A2与细胞迁移和血栓素B2水平密切相关。这证实了磷脂酶A2的亚细胞定位与其生理作用相关，特别是表明细胞相关的酶而非细胞外酶是类花生酸产生的原因。