Ovarian superstimulation and intrauterine insemination for the treatment of unexplained infertility.

OBJECTIVE

To evaluate the efficacy of controlled ovarian hyperstimulation (COH) and IUI in the treatment of unexplained infertility.

DESIGN

The pregnancy rate (PR) in patients with unexplained infertility treated by COH and IUI (group A) was compared with a no-treatment control (group B).

SETTING

The Egyptian IVF-ET Center.

PARTICIPANTS

Four hundred ninety-two patients with the diagnosis of unexplained infertility.

INTERVENTION

Controlled ovarian hyperstimulation and IUI.

MAIN OUTCOME MEASURES

Cycle fecundity per treatment cycle and PR per patient.

RESULTS

In group A cycle fecundity was 20.1% per treatment cycle, and the PR was 34.7% per patient. In group B the PR was 8.9% per patient. Pregnancy rate per patient was significantly higher in group A when compared with the spontaneous PR in group B.

CONCLUSION

Controlled ovarian hyperstimulation and IUI significantly increased the PR in patients with unexplained infertility when compared with a no-treatment control group.