Chen X, Wu Y, Ran R, Meng X, Li Y
Hua Xi Yi Ke Da Xue Xue Bao. 1993 Mar;24(1):45-8.
Hydroxyapatite (HA) bioceramics is a biomaterial used in orthopedic area. We observed its anticancer effect in experimental hepatoma-22 (H22) in mice. BALB/c mice implanted with H22 were grouped into I, II, III and IV. Intratumoral injections were given as follows: (I) HA 0.1 g and ADM 0.1 mg n = 28; (II) HA 0.1 g n = 16; (III) ADM 0.1 mg n = 16; (IV) untreated n = 20. The tumor regression rates of the groups I, II and III were 65.9%, 41.9% and 51.1%, respectively. The mean survivals of groups I, II, III and IV were 32, 22, 26 and 18 days. Six mice of group I were alive more than 50 days before being killed, in which 4 tumor samples showed that no residual tumor cells could be seen under microscope. The possible mechanism of HA anti-cancer action is: (1) the dissolved matter of HA, glycoprotein and microfibril around the tumor cells may disturb the metabolism of cancer; (2) fibrocalcific process restricts the tumor growth; (3) immunoenhancement action (4) as a drug-release system HA is a hopeful agent of intratumoral injection for treatment of cancer.
羟基磷灰石（HA）生物陶瓷是一种应用于骨科领域的生物材料。我们观察了其对小鼠实验性肝癌-22（H22）的抗癌作用。将接种H22的BALB/c小鼠分为I、II、III和IV组。瘤内注射情况如下：（I）HA 0.1 g和阿霉素0.1 mg，n = 28；（II）HA 0.1 g，n = 16；（III）阿霉素0.1 mg，n = 16；（IV）未治疗，n = 20。I、II和III组的肿瘤消退率分别为65.9%、41.9%和51.1%。I、II、III和IV组的平均生存期分别为32天、22天、26天和18天。I组有6只小鼠在处死前存活超过50天，其中4个肿瘤样本在显微镜下显示未见残留肿瘤细胞。HA抗癌作用的可能机制为：（1）HA的溶解产物、肿瘤细胞周围的糖蛋白和微纤维可能干扰癌症代谢；（2）纤维钙化过程限制肿瘤生长；（3）免疫增强作用；（4）作为药物释放系统，HA是一种有希望的瘤内注射治疗癌症的药物。
