Zhang T, Yang Z, Zeng C, Gou X
Hua Xi Yi Ke Da Xue Xue Bao. 1993 Mar;24(1):92-6.
Timed-pregnant Wistar rats were injected intraperitoneally with V2O5 at 0.33, 1.0 and 3.0 mg/kg/day on days 6-15 of gestation. Maternal toxic symptoms, decreased of weight gain during treatment and placenta weight, increased incidence of embryo-fetus mortality and external or skeletal malformation and fetal growth retardation were observed in the 3.0 mg/kg group. Increased incidence of embryo-fetus mortality and external or skeletal malformation, delayed ossification of bone and decreased placenta weight were observed in the 1.0 mg/kg group. These results indicate that V2O5 is a developmental toxicant with or without obvious maternal toxicity in Wistar rats. Although vanadium can be accumulated in placenta, it could passed through placenta. In this study, vanadium could induce a decrease of placenta weight without obvious maternal toxicity, and an A/D ratio of 3 was noted. These results suggest that vanadium may exert a direct effect on embryo-fetues or a "double effect" on the placenta function and embryo-fetus both. It has been reported that vanadium does not increase mal formation in NIN, Kunming, Swiss, NMRI mice or Syrian golden hamster. The dose for inducing developmental toxicity of vanadium in mice is higher than that in rats. This suggests that rats be more sensitive than mice to the developmental toxicity of vanadium.
在妊娠第6至15天，对处于特定孕期的Wistar大鼠腹腔注射五氧化二钒，剂量分别为0.33、1.0和3.0毫克/千克/天。在3.0毫克/千克组中观察到母体出现中毒症状、治疗期间体重增加和胎盘重量下降、胚胎-胎儿死亡率以及外部或骨骼畸形的发生率增加和胎儿生长迟缓。在1.0毫克/千克组中观察到胚胎-胎儿死亡率以及外部或骨骼畸形的发生率增加、骨化延迟和胎盘重量下降。这些结果表明，五氧化二钒是一种发育毒物，在Wistar大鼠中具有或不具有明显的母体毒性。虽然钒可在胎盘中蓄积，但它可以穿过胎盘。在本研究中，钒可在无明显母体毒性的情况下导致胎盘重量下降，且观察到A/D比为3。这些结果表明，钒可能对胚胎-胎儿产生直接影响，或对胎盘功能和胚胎-胎儿均产生“双重影响”。据报道，钒不会增加NIN、昆明、瑞士、NMRI小鼠或叙利亚金黄地鼠的畸形率。钒在小鼠中诱导发育毒性的剂量高于大鼠。这表明大鼠对钒的发育毒性比小鼠更敏感。
