Zhang T, Gou X, Yang Z
Department of Environmental Health.
Hua Xi Yi Ke Da Xue Xue Bao. 1991 Jun;22(2):192-5.
There is no general agreement yet about the teratogenic effects or developmental toxicity of vanadium in animal studies. This is a report on developmental toxicity in NIH mice following injection of vanadium pentoxide (V2O5, 5 mg/kg body weight, i.p.) at different times of gestation (on days 1-5, 6-15, 7, 8, 9, 10, 11, 14-17 of gestation). No adverse effects of V2O5 on pre-implantation and implantation were noted, and neither were teratogenicity and premature birth. However, there was toxic effect on embryofetus. Increased frequency of resorption or fetal death on days 6-15, 7, 14-17 of gestation were observed. Delayed ossification of bones was noted on days 6-15, 8, 10, 14-17 of gestation. These results suggest that V2O5 may be a weak developmental toxicant but not a teratogen in NIH mice. In addition, this paper reports the developmental toxicity, especially teratogenicity of N, N'-methylene-bis (2-amino-1, 3, 4-thiadiazole) which was used as the positive control in NIH mice.
关于钒在动物研究中的致畸作用或发育毒性，目前尚无普遍共识。本文报告了在妊娠不同时期（妊娠第1 - 5天、6 - 15天、7天、8天、9天、10天、11天、14 - 17天）给NIH小鼠腹腔注射五氧化二钒（V2O5，5毫克/千克体重）后的发育毒性。未观察到V2O5对植入前和植入过程有不良影响，也未发现致畸性和早产情况。然而，对胚胎胎儿存在毒性作用。在妊娠第6 - 15天、7天、14 - 17天观察到吸收或胎儿死亡频率增加。在妊娠第6 - 15天、8天、10天、14 - 17天观察到骨骼骨化延迟。这些结果表明，V2O5在NIH小鼠中可能是一种弱发育毒物，但不是致畸剂。此外，本文报告了用作NIH小鼠阳性对照的N，N'-亚甲基双（2 - 氨基 - 1，3，4 - 噻二唑）的发育毒性，尤其是致畸性。
