Hadjipavlou A, Lander P, Antoniou J, Levine J, Dupuis P
Jewish General Hospital, Montreal, Quebec, Canada.
Int Orthop. 1993;17(3):148-53. doi: 10.1007/BF00186375.
One hundred patients who meet McCulloch's indicators for treatment of lumbar disc herniation by chemonucleolysis were entered in this study. Chemonucleolysis in the patients suffering from sciatica secondary to a compression injury, especially with clinical and radiographic evidence of nerve root compression at a single level, can be expected to attain good to excellent results. Chemonucleolysis is far less efficacious in patients suffering from either torsional injury or multiple level abnormality, especially in the absence of neurological deficit. Meticulous attention to patient selection will yield optimal results. The result was excellent or very good in 60% of patients, while in 40% the procedure failed. The rate of success at the L.5/S.1 level was 70%, at the L.4/5 level it was 63% and 37% were successful when multiple levels were treated.
100例符合麦卡洛克化学髓核溶解术治疗腰椎间盘突出症指标的患者纳入本研究。对于因压迫性损伤继发坐骨神经痛的患者，尤其是有单一节段神经根受压的临床和影像学证据时，化学髓核溶解术有望取得良好至极佳的效果。化学髓核溶解术对扭转型损伤或多节段异常的患者疗效要差得多，尤其是在没有神经功能缺损的情况下。严格注意患者的选择才能取得最佳效果。60%的患者结果为优或良，而40%的患者手术失败。L.5/S.1节段的成功率为70%，L.4/5节段为63%，多节段治疗时成功率为37%。
