Schmid-Schönbein H, Rieger H, Hess H
Klin Wochenschr. 1977 Feb 1;55(3):111-9. doi: 10.1007/BF01490238.
The effect of Streptokinase-infusion upon the flow properties of blood was investigated by viscometric and aggregometric methods. Under fibrinolytic therapy, we found in all cases a significant fall in fibrinogen content, as well as a strong reduction in plasma viscosity, velocity of red cell aggregate formation and shear resistance of red cell aggregates. In addition, a drop in apparent blood viscosity at all shear rates was found. In no case, a total desaggregation of red cell was noted. The hematocrit value remained practically constant; consequently, the drop in apparent blood viscosity at high (160 s-1) shear rates and intermediate (8 s-1) shear rates can be solely accounted for by the observed drop in plasma viscosity. At low shear rates (2.3 s-1) the observed drop in apparent viscosity is partly caused by aggregation desaggregation, but mainly by a drop in plasma viscosity. The presented results again confirm that the method of rotational viscometry only incompletely records the improvement in the flow properties of blood that are caused by a therapy aimed at a reduction of the plasma fibrinogen content.
采用粘度测定法和凝集测定法研究了链激酶输注对血液流动特性的影响。在纤维蛋白溶解疗法下，我们发现所有病例的纤维蛋白原含量均显著下降，同时血浆粘度、红细胞聚集体形成速度和红细胞聚集体的剪切阻力也大幅降低。此外，发现在所有剪切速率下表观血液粘度均下降。在任何情况下，均未观察到红细胞完全解聚。血细胞比容值实际上保持恒定；因此，在高剪切速率（160 s-1）和中等剪切速率（8 s-1）下表观血液粘度的下降完全可归因于观察到的血浆粘度下降。在低剪切速率（2.3 s-1）下，观察到的表观粘度下降部分是由聚集解聚引起的，但主要是由血浆粘度下降引起的。所呈现的结果再次证实，旋转粘度测定法只能不完全记录旨在降低血浆纤维蛋白原含量的疗法所引起的血液流动特性的改善情况。
