Beardslee W R, Keller M B, Lavori P W, Staley J, Sacks N
Judge Baker Children's Center, Department of Psychiatry, Boston, MA 02115.
J Am Acad Child Adolesc Psychiatry. 1993 Jul;32(4):723-30. doi: 10.1097/00004583-199307000-00004.
This study explored the effects of parental affective disorder on offspring in a nonreferred health maintenance organization 4 years after initial examination.
The sample, average age 18.5 years, included 91% of the 153 youngsters initially studied. The main instruments were structured diagnostic interviews scored according to criterion systems for both parents and children; assessment of the youngsters was blind to the previous assessment.
Rates of major depressive disorder were higher in the children of parents with affective disorder (26%) compared with those whose parents had no disorder (10%).
Depression and other parental affective disorders, as they occur in the community in parents who often are neither recognized nor treated, are associated with serious affective disorder in offspring. Clinical and preventive approaches for these offspring are needed and should be targeted to all families in which there is serious parental affective disorder, not just those who present for psychiatric treatment.
本研究在初次检查4年后，对一家非转诊式健康维护组织中的后代进行研究，以探究父母情感障碍对其的影响。
样本平均年龄为18.5岁，包括最初研究的153名青少年中的91%。主要工具是根据针对父母和孩子的标准系统进行评分的结构化诊断访谈；对青少年的评估对先前的评估结果不知情。
与父母无情感障碍的孩子（10%）相比，父母患有情感障碍的孩子中，重度抑郁症的发病率更高（26%）。
抑郁症和其他父母情感障碍，在社区中常发生于未被识别和治疗的父母身上，与后代严重的情感障碍有关。需要针对这些后代的临床和预防方法，且应针对所有存在严重父母情感障碍的家庭，而不仅仅是那些寻求精神科治疗的家庭。
