Todd R D, Reich W, Reich T
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
J Am Acad Child Adolesc Psychiatry. 1994 Feb;33(2):198-207. doi: 10.1097/00004583-199402000-00007.
The study determined the prevalence of psychiatric disorders among the child and adolescent offspring of an extended family identified through a proband with bipolar affective disorder.
All of the not mentally retarded offspring (ages 6 to 17 years) of a single extended bipolar affective disorder pedigree were studied. Data regarding psychiatric diagnoses, intelligence, school achievement, temperament, and family functioning were collected using structured and standardized instruments.
When the child and adolescent offspring were stratified by degree of genetic relationship to an adult with an affective disorder, there were no differences in demographic variables, IQ, school achievement, or most temperamental and family characteristics. In contrast, there were increases in the rates of affective disorders and disruptive behavior disorders in the offspring that correlated with the degree of genetic relationship to an affected adult.
The risk of developing an early onset affective disorder is correlated with the degree of genetic relatedness to affected adults in this single, extended family. This pilot study demonstrates that the inclusion of extended relatives in high-risk studies can enhance the discrimination of genetic and environmental contributions to the development of affective disorders.
本研究确定了通过一名双相情感障碍先证者确定的一个大家庭中儿童和青少年后代精神障碍的患病率。
对一个单一的双相情感障碍扩展谱系中所有无智力障碍的后代（6至17岁）进行了研究。使用结构化和标准化工具收集有关精神疾病诊断、智力、学业成绩、气质和家庭功能的数据。
当儿童和青少年后代按与情感障碍成年人的遗传关系程度分层时，在人口统计学变量、智商、学业成绩或大多数气质和家庭特征方面没有差异。相比之下，后代中情感障碍和破坏性行为障碍的发生率增加，且与与受影响成年人的遗传关系程度相关。
在这个单一的大家庭中，早发性情感障碍的发病风险与与受影响成年人的遗传关系程度相关。这项初步研究表明，在高危研究中纳入扩展亲属可以增强对情感障碍发展中遗传和环境因素的区分。
