Taniguchi Y, Sakamoto T, Shimizu M
Department of Dermatology, Mie University School of Medicine, Tsu, Japan.
J Dermatol. 1993 May;20(5):304-7. doi: 10.1111/j.1346-8138.1993.tb01396.x.
A 43-year-old woman had asymptomatic eruptions on the anterior sides of both legs for 5 years. Biopsy specimens revealed the typical findings of necrobiosis lipoidica. An immunofluorescence study demonstrated no deposits of immunoglobulins, complement, or fibrinogen in vessel walls. Immunohistochemical staining revealed CD4 positive lymphocytes dominating in the lesion and strong expression of ICAM-1 on the endothelial cells, giant cells, lymphocytes and dermal fibroblasts in the lesion. The eruptions resolved remarkably with oral corticosteroid therapy.
一名43岁女性双下肢前侧出现无症状皮疹5年。活检标本显示出类脂质渐进性坏死的典型表现。免疫荧光研究表明血管壁中无免疫球蛋白、补体或纤维蛋白原沉积。免疫组织化学染色显示病变中以CD4阳性淋巴细胞为主，病变中的内皮细胞、巨细胞、淋巴细胞和真皮成纤维细胞上ICAM-1呈强表达。口服皮质类固醇治疗后皮疹明显消退。
