法国暴发性乙型肝炎中乙肝病毒DNA前C区突变的低发生率
Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France.
作者信息
Féray C, Gigou M, Samuel D, Bernuau J, Bismuth H, Bréchot C
机构信息
Hybridotest, Institut Pasteur, Paris, France.
出版信息
J Hepatol. 1993 Apr;18(1):119-22. doi: 10.1016/s0168-8278(05)80019-4.
The presence of mutants of the precore region of the hepatitis B virus genome was investigated in French patients with fulminant hepatitis. Only one of the 10 subjects had a detectable mutation by direct sequencing. On the other hand, 2/10 and 3/10 had evidence of coinfection by hepatitis D virus and hepatitis C virus. These results indicate that the precore stop mutation at codon 28 is not a general condition in fulminant hepatitis B and might reflect epidemiological factors.
对法国暴发性肝炎患者的乙型肝炎病毒基因组前核心区突变体的存在情况进行了研究。10名受试者中只有1人通过直接测序检测到突变。另一方面，10人中有2人以及10人中有3人有丁型肝炎病毒和丙型肝炎病毒合并感染的证据。这些结果表明，第28位密码子的前核心终止突变并非暴发性乙型肝炎的普遍情况，可能反映了流行病学因素。
Zotero 插件