乙肝病毒前核心突变体在乙肝地方流行区的急性和慢性感染中普遍存在。
Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic.
作者信息
Chu C M, Yeh C T, Chiu C T, Sheen I S, Liaw Y F
机构信息
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung Medical College, Taipei, Taiwan.
出版信息
J Clin Microbiol. 1996 Jul;34(7):1815-8. doi: 10.1128/JCM.34.7.1815-1818.1996.
Abstract
By using an amplification-created restriction site method, the precore TAG mutant of hepatitis B virus was detected in 6 (75%) of 8 acute fulminant hepatitis B patients, 7 (58%) of 12 acute self-limiting hepatitis B patients, 35 (81%) of 43 hepatitis B virus surface antigen carriers with fulminant hepatitis, and 42 (70%) of 60 hepatitis B virus surface antigen carriers with chronic hepatitis. The precore TAG mutant prevails in acute and chronic hepatitis B of various severity in this area where hepatitis B is endemic.
摘要
采用扩增产生的限制性酶切位点法，在8例急性重型乙型肝炎患者中的6例（75%）、12例急性自限性乙型肝炎患者中的7例（58%）、43例重型肝炎乙型肝炎病毒表面抗原携带者中的35例（81%）以及60例慢性乙型肝炎乙型肝炎病毒表面抗原携带者中的42例（70%）检测到了乙型肝炎病毒前核心TAG突变体。在这个乙型肝炎地方流行区，前核心TAG突变体在各种严重程度的急慢性乙型肝炎中都很常见。
相似文献
1
Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic.乙肝病毒前核心突变体在乙肝地方流行区的急性和慢性感染中普遍存在。
J Clin Microbiol. 1996 Jul;34(7):1815-8. doi: 10.1128/JCM.34.7.1815-1818.1996.
2
Detection of hepatitis B virus precore stop codon mutants by selective amplification method: frequent detection of precore mutants in hepatitis B e antigen positive healthy carriers.
J Gastroenterol Hepatol. 1995 Jul-Aug;10(4):419-25. doi: 10.1111/j.1440-1746.1995.tb01594.x.
3
Genetic heterogeneity in the precore region of hepatitis B virus in hepatitis B e antigen-negative chronic hepatitis B patients: spontaneous seroconversion and interferon-induced seroconversion.乙型肝炎e抗原阴性慢性乙型肝炎患者中乙型肝炎病毒前核心区的基因异质性：自然血清学转换和干扰素诱导的血清学转换
J Med Virol. 1995 Apr;45(4):373-80. doi: 10.1002/jmv.1890450404.
4
Novel application of a point mutation assay: evidence for transmission of hepatitis B viruses with precore mutations and their detection in infants with fulminant hepatitis B.
J Med Virol. 1994 Sep;44(1):13-21. doi: 10.1002/jmv.1890440105.
5
Emergence of precore TAG mutation during hepatitis B e seroconversion and its dependence on pregenomic base pairing between nucleotides 1858 of 1896.乙肝e抗原血清学转换期间前核心TAG突变的出现及其对1896位核苷酸1858处前基因组碱基配对的依赖性。
J Infect Dis. 1995 Nov;172(5):1343-7. doi: 10.1093/infdis/172.5.1343.
6
Precore mutant of hepatitis B virus in childhood fulminant hepatitis B: an infrequent association.儿童暴发性乙型肝炎中的乙肝病毒前核心突变：一种罕见的关联。
J Infect Dis. 1995 Apr;171(4):776-81. doi: 10.1093/infdis/171.4.776.
7
Association between frequency of amino acid changes in core region of hepatitis B virus (HBV) and the presence of precore mutation in Japanese HBV carriers.日本乙肝病毒携带者中乙肝病毒核心区域氨基酸变化频率与前核心突变存在情况之间的关联
J Gastroenterol. 1997 Oct;32(5):611-22. doi: 10.1007/BF02934110.
8
Hepatitis B virus precore mutation and fulminant hepatitis in the United States. A polymerase chain reaction-based assay for the detection of specific mutation.美国的乙型肝炎病毒前核心区突变与暴发性肝炎。一种基于聚合酶链反应的特定突变检测方法。
J Clin Invest. 1994 Feb;93(2):550-5. doi: 10.1172/JCI117006.
9
Precore stop codon mutant in chronic hepatitis B virus infection in children: its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen.
J Hepatol. 1998 Jun;28(6):915-22. doi: 10.1016/s0168-8278(98)80337-1.
10
Nucleotide sequence of precore region of hepatitis B virus DNA in HBsAg-positive carriers in Malaysia.马来西亚乙肝表面抗原阳性携带者中乙肝病毒DNA前核心区的核苷酸序列。
Scand J Infect Dis. 1996;28(6):543-8. doi: 10.3109/00365549609037957.
引用本文的文献
1
G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B.慢性乙型肝炎患者中G1896A前核心区突变及其与HBeAg状态、基因型和临床状态的关联
Hepat Mon. 2015 Oct 28;15(10):e31490. doi: 10.5812/hepatmon.31490. eCollection 2015 Oct.
2
New perspective on the natural course of chronic HBV infection.慢性乙型肝炎病毒感染自然病程的新视角
Front Med. 2014 Jun;8(2):129-34. doi: 10.1007/s11684-014-0339-x. Epub 2014 May 29.
3
Basal core promoter mutation is associated with progression to cirrhosis rather than hepatocellular carcinoma in chronic hepatitis B virus infection.基础核心启动子突变与慢性乙型肝炎病毒感染向肝硬化进展相关，而非与肝细胞癌相关。
Br J Cancer. 2012 Dec 4;107(12):2010-5. doi: 10.1038/bjc.2012.474. Epub 2012 Oct 18.
4
Viral load, genotypes, and mutants in hepatitis B virus-related hepatocellular carcinoma: special emphasis on patients with early hepatocellular carcinoma.乙型肝炎病毒相关肝细胞癌中的病毒载量、基因型和突变体：特别强调早期肝细胞癌患者。
Dig Dis Sci. 2012 Jan;57(1):232-8. doi: 10.1007/s10620-011-1844-2. Epub 2011 Aug 12.
5
Role of viral factors in the natural course and therapy of chronic hepatitis B.病毒因素在慢性乙型肝炎自然病程和治疗中的作用。
Hepatol Int. 2007 Dec;1(4):415-30. doi: 10.1007/s12072-007-9033-2. Epub 2007 Oct 12.
6
Distribution of hepatitis B viral genotypes and mutations in the core promoter and precore regions in acute forms of liver disease in patients from Chiba, Japan.日本千叶县急性肝病患者中乙型肝炎病毒基因型分布及核心启动子和前核心区的突变情况
Gut. 2003 Nov;52(11):1630-7. doi: 10.1136/gut.52.11.1630.
7
Molecular, immunological and clinical properties of mutated hepatitis B viruses.乙型肝炎病毒变异体的分子、免疫学及临床特性
J Cell Mol Med. 2002 Jan-Mar;6(1):113-43. doi: 10.1111/j.1582-4934.2002.tb00317.x.
8
Precore stop mutant in HBeAg-positive patients with chronic hepatitis B: clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion.HBeAg阳性慢性乙型肝炎患者前核心区终止突变体：临床特征及其与HBeAg血清学转换过程的相关性
J Clin Microbiol. 2002 Jan;40(1):16-21. doi: 10.1128/JCM.40.1.16-21.2002.
本文引用的文献
1
Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States.美国暴发性乙型肝炎患者前核心区的核苷酸序列分析。
Gastroenterology. 1993 Oct;105(4):1173-8. doi: 10.1016/0016-5085(93)90964-e.
2
Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France.法国暴发性乙型肝炎中乙肝病毒DNA前C区突变的低发生率
J Hepatol. 1993 Apr;18(1):119-22. doi: 10.1016/s0168-8278(05)80019-4.
3
Variations of hepatitis B virus precore/core gene sequence in acute and fulminant hepatitis B.
Dig Dis Sci. 1994 Jun;39(6):1281-7. doi: 10.1007/BF02093794.
4
The role of hepatitis C virus in fulminant viral hepatitis in an area with endemic hepatitis A and B.在甲型和乙型肝炎流行地区丙型肝炎病毒在暴发性病毒性肝炎中的作用
Gastroenterology. 1994 Jul;107(1):189-95. doi: 10.1016/0016-5085(94)90076-0.
5
Absence of precore stop mutant in chronic dual (B and C) and triple (B, C, and D) hepatitis virus infection.慢性双重（B和C型）及三重（B、C和D型）肝炎病毒感染中前核心区终止突变体的缺失
J Infect Dis. 1994 Dec;170(6):1582-5. doi: 10.1093/infdis/170.6.1582.
6
Precore mutant of hepatitis B virus in childhood fulminant hepatitis B: an infrequent association.儿童暴发性乙型肝炎中的乙肝病毒前核心突变：一种罕见的关联。
J Infect Dis. 1995 Apr;171(4):776-81. doi: 10.1093/infdis/171.4.776.
7
Natural history of chronic hepatitis B virus infection in Taiwan: studies of hepatitis B virus DNA in serum.台湾慢性乙型肝炎病毒感染的自然史：血清中乙型肝炎病毒DNA的研究
Hepatology. 1985 May-Jun;5(3):431-4. doi: 10.1002/hep.1840050315.
8
Changes of serum HBV-DNA in relation to serum transaminase level during acute exacerbation in patients with chronic type B hepatitis.慢性乙型肝炎患者急性加重期血清HBV-DNA与血清转氨酶水平的关系变化
Liver. 1988 Aug;8(4):231-5. doi: 10.1111/j.1600-0676.1988.tb00998.x.
9
Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection.慢性乙型肝炎感染患者中阻止乙肝e抗原形成的突变。
Lancet. 1989 Sep 9;2(8663):588-91. doi: 10.1016/s0140-6736(89)90713-7.
10
The etiology of acute hepatitis superimposed upon previously unrecognized asymptomatic HBsAg carriers.先前未被识别的无症状乙肝表面抗原携带者发生急性肝炎的病因。
Hepatology. 1989 Mar;9(3):452-6. doi: 10.1002/hep.1840090319.
Zotero 插件