Voss G, Hunsmann G
Deutsches Primatenzentrum, Abteilung Virologie und Immunologie, Göttingen, Germany.
J Acquir Immune Defic Syndr (1988). 1993 Sep;6(9):969-76.
SIV and HIV-2 infection of macaques has become a widely used model to study human HIV infection because the pathogenicity of, as well as the immune responses to, the viruses can be examined conveniently. In particular, the cellular immune responses to SIV or HIV-2 have been investigated thoroughly. This review summarizes the knowledge about helper and cytotoxic T-cell immunity in macaques, and it discusses the relevance and applications of this primate animal model for AIDS research.
猕猴感染猴免疫缺陷病毒（SIV）和人类免疫缺陷病毒2型（HIV-2）已成为研究人类HIV感染的一种广泛应用的模型，因为可以方便地检测这些病毒的致病性以及免疫反应。特别是，对SIV或HIV-2的细胞免疫反应已得到深入研究。本综述总结了关于猕猴辅助性和细胞毒性T细胞免疫的知识，并讨论了这种灵长类动物模型在艾滋病研究中的相关性和应用。
