Wang S J, Lin W Y, Hsu C Y, Kao C H, Chang C P, Lan J L
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1993 Jun;9(6):338-42.
Polymyositis (PM) and dermatomyositis (DM) may be associated with motor dysfunction of the entire gastrointestinal tract. Abnormal esophageal motor function is a well-recognized complication of these diseases. In this study, we used a solid phase esophageal study to evaluate the motor function in patients with PM or DM. Twenty-three patients and 36 age-matched normal volunteers were studied. Each subject was placed in a supine position above a gamma camera linked to a computer and was given a 4-ml bolus of solid gelatin containing 1 mCi of Tc-99m phytate. Data were acquired in the list mode. A computer method modified from Kelim and Wald and Russell et al. was used to calculate the following: A) total mean transit time (MTT); B) residual fraction after the first swallow (RF); and C) retrograde index (RI). All values are presented as mean +/- standard deviation (SD). The Student's t-test was used to test statistical significance. Our preliminary results suggest: 1) delayed esophageal emptying is common (17/23) in PM/DM, indicating frequent malfunction of the smooth muscle of the upper gastrointestinal tract in PM/DM and 2) measurement of esophageal motility may monitor disease activity in PM/DM.
多发性肌炎（PM）和皮肌炎（DM）可能与整个胃肠道的运动功能障碍有关。食管运动功能异常是这些疾病公认的并发症。在本研究中，我们使用固相食管研究来评估PM或DM患者的运动功能。研究了23例患者和36名年龄匹配的正常志愿者。每个受试者仰卧在与计算机相连的γ相机上方，给予4毫升含1毫居里锝-99m植酸盐的固体明胶丸剂。数据以列表模式采集。采用一种从Kelim和Wald以及Russell等人修改而来的计算机方法来计算以下指标：A）总平均通过时间（MTT）；B）首次吞咽后的残留分数（RF）；C）逆行指数（RI）。所有值均以平均值±标准差（SD）表示。采用Student t检验来检验统计学意义。我们的初步结果表明：1）PM/DM中食管排空延迟很常见（17/23），表明PM/DM中上消化道平滑肌频繁出现功能障碍；2）食管动力测量可能监测PM/DM中的疾病活动。
